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AIDS:
doi: 10.1097/QAD.0b013e3282ff624e
Epidemiology and Social

The efficacy of behavioral interventions in reducing HIV risk behaviors and incident sexually transmitted diseases in heterosexual African Americans

Darbes, Lynaea; Crepaz, Nicoleb; Lyles, Cynthiab; Kennedy, Gailc; Rutherford, Georgec

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Erratum
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Erratum

Due to an error at the Publisher's office the web address noting the location of the Appendix, was omitted in ‘The efficacy of behavioral interventions in reducing HIV risk behaviors and incident sexually transmitted diseases in heterosexual African Americans' by Darbes et al. [1] which appeared on pp. 1177–1194 of AIDS, Volume 22, issue 10.

Please find the web address below:

http://www.igh.org/aids-appendix

AIDS. 22(12):i, July 31, 2008.

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Author Information

From the aCenter for AIDS Prevention Studies and Global Health Sciences, University of California, San Francisco, USA

bCenters for Disease Control and Prevention and HIV/AIDS Prevention Research Synthesis (PRS) Team, USA

cGlobal Health Sciences, UCSF and Cochrane Collaborative Review Group on HIV Infection and AIDS, San Francisco, California, USA.

Received 5 April, 2007

Revised 5 February, 2008

Accepted 6 February, 2008

Correspondence to Lynae Darbes, PhD, Center for AIDS Prevention Studies, UCSF, 50 Beale St, Suite 1300, San Francisco, CA 94105, USA. E-mail: lynae.darbes@ucsf.edu

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Abstract

Objective: To conduct a meta-analytic review of HIV interventions for heterosexual African Americans to determine the overall efficacy in reducing HIV-risk sex behaviors and incident sexually transmitted diseases and identify intervention characteristics associated with efficacy.

Methods: Comprehensive searches included electronic databases from 1988 to 2005, handsearches of journals, reference lists of articles, and contacts with researchers. Thirty-eight randomized controlled trials met the selection criteria. Random-effects models were used to aggregate data.

Results: Interventions significantly reduced unprotected sex (odds ratio = 0.75; 95% confidence interval = 0.67, 0.84; 35 trials; N = 14 682) and marginally significantly decreased incident sexually transmitted diseases (odds ratio = 0.88; 95% confidence interval = 0.72, 1.07; 10 trials; N = 10 944). Intervention characteristics associated with efficacy include cultural tailoring, aiming to influence social norms in promoting safe sex behavior, utilizing peer education, providing skills training on correct use of condoms and communication skills needed for negotiating safer sex, and multiple sessions and opportunities to practice learned skills.

Conclusion: Interventions targeting heterosexual African Americans are efficacious in reducing HIV-risk sex behaviors. Efficacious intervention components identified in this study should be incorporated into the development of future interventions and further evaluated for effectiveness.

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Introduction

Heterosexual African Americans are disproportionately impacted by HIV [1,2]. A myriad of factors has been suggested for this finding, ranging from limited access to healthcare to the broader societal repercussions of racism and poverty. The impact of the HIV epidemic among African Americans underscores the importance of identifying efficacious behavioral interventions to reduce the risk of acquiring HIV through sexual behavior. Numerous interventions targeting sexual risk reduction among heterosexual African Americans have been evaluated in recent years; however, the empirical findings have not been examined as a whole. Although several meta-analyses have been conducted to examine the efficacy of HIV behavioral interventions for various populations at risk for HIV infection, including men who have sex with men [3–5], women [6,7], heterosexual men [8], drug users [9,10], adolescents [11,12], Hispanics [13] and sexually transmitted disease (STD) clinic patients [14,15], there is no meta-analysis that provides the overall assessment of intervention efficacy specifically for heterosexual African Americans.

Apart from estimating the overall intervention efficacy, meta-analysis can also identify particular factors (i.e., study design, intervention features) that are associated with intervention efficacy. Qualitative systematic reviews have focused on components of HIV prevention strategies for African Americans specifically [16–19], women of color [20], and culturally competent interventions [21]. All of the reviews recommended including cultural tailoring specific to the community of interest.

To make empirically driven evidence-based recommendations for programmatic efforts and future research, we conducted a meta-analytic review of randomized controlled trials (RCTs) that evaluated HIV behavioral interventions for African–American heterosexual populations in the United States. We restricted this study to only RCTs following the Cochrane Collaboration principles, which recommend focusing on RCTs for synthesizing clinical and behavioral research findings and providing the best evidence as to intervention efficacy [22]. Given methodological issues, we restricted our analyses to individual-level and group-level interventions. Our specific goals included assessing the overall efficacy of interventions in reducing heterosexual transmission of HIV among African Americans regardless of drug using status, identifying characteristics of the studies, samples and interventions that are associated with intervention efficacy, and highlighting research gaps for this population.

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Methods

Data source

As part of the HIV/AIDS Prevention Research Synthesis (PRS) project [23] of the Centers for Disease Control (CDC), we developed multiple search strategies to identify published and unpublished RCTs evaluating interventions to reduce HIV sex risk behaviors among heterosexual African Americans between 1988 and 2005 (J.B. Deluca, M.M. Mullins, C.M. Lyles, N. Crepaz, L. Kay, S. Thadiparthi, the HIV/AIDS Prevention Research Synthesis (PRS) Team, unpublished observation). We developed an automated systematic search using standardized search terms cross-referenced in three areas: HIV, AIDS, or STD; intervention evaluation; and behavioral or biologic outcomes. We searched multiple electronic bibliographic databases including AIDSLINE (1988–2000), EMBASE, MEDLINE, PsycINFO, and Sociological Abstracts from 1988 to 2005. For each database, we searched unique index terms supplemented with keywords and phrases. We also manually searched 35 key journals, which regularly publish HIV or STD prevention research, to locate additional reports for the period January 2004 to December 2005 and checked reference lists of pertinent reports to identify additional reports. Finally, we contacted researchers and research organizations for current and on-going research. Complete descriptions of the search strategies and terms are available on request.

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Trial selection

Relevant studies were included in this review if they met all of the following criteria:

1. Evaluated individual-level or group-level interventions specifically designed to change risky sex behaviors in efforts to decrease the risk of heterosexual transmission of HIV.

2. Employed an RCT design.

3. Focused on or specifically targeted African Americans, or consisted of at least 80% African–American participants.

4. Were conducted in the United States.

5. Measured any of the following sex risk behavior and biologic variables:

a. any unprotected insertive or receptive anal intercourse, unprotected vaginal insertive or receptive intercourse,

b. consistency of condom use, or

c. incident STD.

6. Reported at least one postintervention outcome.

7. Reported sufficient descriptive data or statistical tests of the intervention effects necessary to calculate an effect size. We contacted authors to obtain additional information as needed.

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Data extraction

Trained pairs of reviewers independently abstracted information from eligible reports. We identified linkages among reports to ensure that multiple reports describing an intervention were included in the coding and data analysis. We coded each intervention using a standardized coding form for trial information (e.g., intervention dates, location), participant characteristics (e.g., age, sex), outcomes [type of outcome, follow-up time, STD measurement and assays (see Appendix available online)], and intervention features (theory-based, delivery method). We coded for specific features for culturally tailored interventions such as statements of cultural appropriateness, ethnically matched deliverer, and ethnographic research. We assessed the methodological quality of the studies by assessing randomization (sequence generation, allocation concealment, blinding), type of control group, participation rate, overall and differential retention rate, power analysis, and intent-to-treat analysis based on the modified Jadad criteria for RCTs [24]. There was a 90% agreement between reviewers across variables. We reconciled coding discrepancies through discussion.

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Analytic approach

Owing to differences in the studies in terms of the number of arms, type of outcomes, analyses conducted, and findings reported, we used the following rules for abstracting information for meta-analysis. To meet the independence of the effect size assumption, for trials with multiple arms, we selected the contrast between the intervention arm that was most theoretically potent and the comparison arm that was typically a standard of care or wait list control. Separate analyses were conducted for sex outcomes and laboratory/clinical diagnosis of incident STDs. To prevent the correlations from multiple effect size estimates within a single study from biasing the results, we selected unprotected sex over condom use for studies that reported both measures. If a trial reported outcome data at two or more follow-ups, we selected the first follow-up for the overall effect size. Finally, to ensure that nonequivalent groups at baseline did not confound the results, we adjusted for baseline sexual behavior differences if the information was available [25,26].

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Meta-analytic methods

We used odds ratios (ORs) to present the magnitude of intervention effects. For trials reporting means and standard deviations on continuous outcomes, we calculated standardized mean differences and then converted into ORs [4]. We used standardized meta-analytical methods [26,27] to calculate individual effect size and combine effect sizes across studies. We used the natural logarithm to obtain log of odds ratios (ln OR) and calculated its corresponding weight (inverse variance) for each study. In estimating the overall effect size, we multiplied each ln OR by its weight, summed the weighted ln ORs across trials, and then divided it by the sum of the weights. We then converted the aggregated ln OR back to OR and derived a 95% confidence interval (95% CI). We also examined the heterogeneity of the effect sizes by using the Q-statistic. We tested both fixed-effects and random-effects models, and both models yielded similar findings. We base the final presentation on the random-effects model because it provides a more conservative estimate of variance and generates more accurate inferences about a population of trials beyond the set of trials included in this study [28].

We conducted sensitivity analyses to determine the robustness of intervention effects and stratified analyses to determine whether methodological quality, trial, and sample characteristics, or intervention features were associated with effect sizes. We assessed the likelihood of subgroup differences using the between-groups heterogeneity statistics, QB, which has a χ2 distribution and degree of freedom equal to the number of subgroups minus one degree of freedom. We used all the available data and recalculated the overall effect size separately for trials reporting unprotected sex and trials reporting condom use. We examined intervention effects on the sex outcomes at the following follow-up times: less than 3 months, 3 months, 6 months, and longer than 6 months. Similar analyses were conducted for the STD outcomes 6-months and 12-months after intervention. In addition, we compared the aggregated effect size estimate among all trials with the estimate obtained after excluding trials that might influence the overall estimate.

We ascertained publication bias by inspecting a funnel plot [29] and a linear regression test [30], which compared standardized effect size estimate with precision (the inverse of the standard error) of each study.

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Results

Description of trial, sample, and intervention characteristics

Thirty-eight RCTs, including 14 983 participants, met the inclusion criteria (Fig. 1). Descriptive information for each trial is shown in Table 1 [31–68], and summary information of intervention components and design is presented in Table 2. Participants in the majority of the trials included either women only or mixed sex, nondrug users, and people older than 18 years. Approximately half of the trials were set in clinics, whereas the other half were conducted in either community or educational/research settings.

Fig. 1
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Table 1
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Table 2
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With few exceptions, the trials were based on behavioral change theories (e.g., Social Cognitive Theory, Information-Motivation Behavior Model) and two thirds were culturally tailored specifically for African Americans (e.g., ethnically matched facilitators, ethnographic research). Most trials contained multiple intervention components aimed at reducing sexual risk. Skills training components were the most common and took specific forms including correct use of male condoms or negotiating safer sex. Most interventions were delivered in small groups and most trials were comprised of two to five sessions over 2–30 days.

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Methodological quality of the trials

Only a small portion of the trials reported information pertaining to sequence generation (37%), allocation concealment (26%), and blinding (34%). Mean participation rate and retention rate at the first follow-up was 70% among 17 trials reporting participation rates and 73% among 31 trials reporting retention rates. In the majority of the trials, differential retention rates among intervention and comparison groups were less than 10%, but two trials reported differential retention rates greater than 20%. The median sample size at baseline enrollment across all trials was 211. Only one third of the trials reported that power analysis was conducted to estimate the sample size. All trials used intent-to-treat analysis.

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Effect sizes for self-reported HIV risk sexual behavior

Thirty-five RCTs provided data on self-reported HIV risk behavior from 14 682 participants. The aggregated effect size was significant (OR = 0.75, 95% CI = 0.67, 0.84), indicating that the intervention groups had 25% reduction in odds of reporting unprotected sexual behavior compared with comparison groups, at an average of 3 months after intervention. Examination of the forest plot (Fig. 2) and the homogeneity test (Q35 = 50.63, P < 0.05) indicated that there was heterogeneity between trials. However, sensitivity tests did not reveal any individual trial that exerted influence on the overall heterogeneity. Additional sensitivity tests, using all available data, showed that significant intervention effects were observed in studies with a follow-up of less than 3 months (OR = 0.67, 95% CI = 0.51, 0.87, N = 8), approximately 3 months (OR = 0.78, 95% CI = 0.69, 0.89, N = 18), and approximately 6 months (OR = 0.74, 95% CI = 0.61, 0.90, N = 18). Studies with a follow-up longer than 6 months had marginally significant effect on risk reduction (OR = 0.81, 95% CI = 0.62, 1.05, N = 12). Significant intervention effects were observed for unprotected sex (OR = 0.79, 95% CI = 0.71, 0.88, N = 22) and condom use (OR = 0.63, 95% CI = 0.52, 0.75, N = 22).

Fig. 2
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We conducted stratified analyses to further examine heterogeneity among trials. Significantly greater efficacy was found among trials that addressed social norms toward safer sex compared with trials that did not address social norms (QB = 13.02, P < 0.001). Similarly, significantly greater efficacy was found in trials that utilized peer education compared with trials that did not have peer education (QB = 3.83, P = 0.05). A methodological feature associated with differential efficacy was type of comparison group. Trials in which comparison groups also received some HIV intervention components were less efficacious than those in which comparison groups did not receive any HIV-related intervention (QB = 4.51, P < 0.05).

As seen in Table 3, a significant intervention effect was observed in trials regardless of the participant characteristics, methodological quality of trials, or intervention features (i.e., intervention setting, self-efficacy). There were several instances where the aggregated intervention effect size was significant in trials with a specific characteristic (e.g., culturally tailored), whereas the aggregated effect size was not significant in trials without that characteristic. We explored those qualitative differences, as they may provide clues about potentially important factors associated with efficacy (Table 3). Intervention groups were significantly less likely than comparison groups to report unprotected sex in trials that were culturally tailored for African Americans, delivered in a minority community, based on behavioral change theory, provided skills training on correct use of condoms and negotiation of safer sex, had more than one intervention session, had sessions that lasted more than 1 day, and had more than 160 min of cumulative intervention time.

Table 3
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Effect sizes for incident sexually transmitted diseases

Data on incident STDs were available from 10 RCTs that included 10 944 participants. The aggregated effect size was marginally significant (OR = 0.88, 95% CI = 0.72, 1.07), indicating that the intervention groups had a 12% reduction in the odds of incident STD compared with comparison groups. The homogeneity test (Q10 = 18.61, P < 0.03) indicated heterogeneity between trials. Sensitivity tests indicated that excluding one trial [53] made the intervention effect significant (OR = 0.82, 95% CI = 0.69, 0.98, N = 9). However, none of the studies significantly reduced the overall heterogeneity. Additional sensitivity tests showed that marginally significant intervention effects were observed in studies with follow-ups longer than 12 months (OR = 0.77, 95% CI = 0.59, 1.00, N = 7), but the intervention effect was not significant in trials with follow-ups less than 12 months (OR = 1.00, 95% CI = 0.82, 1.21, k = 3).

QB tests did not yield any meaningful group differences, primarily due to the small number of trials. We explored the qualitative differences between trials reporting that characteristic demonstrated a significant intervention effect and those not reporting that characteristic and not demonstrating a significant effect. This pattern was found in four variables based on behavioral change theory, providing trainings on correct use of condom and negotiation of safer sex, addressing social norms about safer sex, and peer education.

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Examination for publication bias

On the basis of the linear regression test, we found evidence of publication bias for 35 trials that provided unprotected sex/condom use outcomes (t = −2.614, P = 0.013). The funnel plot was asymmetrical, suggesting that fewer studies with negative interventions effects and large variance were identified in this study (figure not shown). There is no evidence of publication bias for the STD outcomes (t = −0.631, P = 0.546).

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Discussion

Our study shows that behavioral interventions can significantly and positively influence sexual risk behaviors among heterosexual African Americans. The reduction in unprotected sex remained significant up to 6 months following the completion of interventions. Our overall finding (OR = 0.75) is comparable to the findings of other meta-analyses evaluating HIV prevention interventions for heterosexual adults [8] and adolescents [69]. We also found a marginally significant effect on incident STDs (OR = 0.88), especially at follow-ups greater than 12 months after intervention. However, the effect became significant when eliminating the trial of the lowest methodological quality [53]. This evidence suggests that behavioral interventions can be not only efficacious in changing unprotected sex behaviors but may also reduce incident STDs in heterosexual African Americans.

We identified a number of intervention components associated with risk reduction. Greater efficacy was found for interventions that utilized peer education and aimed to influence social norms about safer sex. Our findings suggest that the influence of peers and the perception of the norms of one's peers should be considered in developing effective interventions for heterosexual African Americans.

When exploring differences between interventions with a particular characteristic to those without that characteristic for the sex outcomes, we identified several patterns that may provide additional information for prevention efforts. Consistent with the findings of previous qualitative studies [16,18,19], cultural tailoring appears to be an important component for reducing sex risk behaviors among heterosexual African Americans. Intriguingly, we did not find any differential efficacy for the particular components of culturally tailored interventions. It is plausible that our inclusion criteria, which stipulated that trials be comprised of at least 80% African–American participants, reduced the variance necessary to detect an effect. More research is needed to assess which specific cultural tailoring components are the active ingredients underlying behavior change.

Additional intervention components that are likely to contribute to behavior change are skills training and negotiation. Utilizing skills training is typical of interventions guided by social cognitive theories, which represent a majority of the interventions in this analysis. There is also evidence of a dose–response relationship regarding number of sessions, time span, and duration of interventions. The independent contributions of these intervention characteristics cannot be disentangled within these data, as the majority of the interventions utilized multiple components and sessions over multiple days. However, the overall findings suggest that behavioral interventions are more likely to be successful if they incorporate skills training and provide opportunities for practicing skills. In addition, future interventions may benefit from utilizing multiple sessions over multiple days, lasting several hours in total length.

The findings of our study must be viewed within the context of the limitations of the available evidence. Interventions we reviewed primarily addressed heterosexual transmission of HIV, although some portions of men may have participated who also engaged in same-sex behavior but did not identify themselves as homosexual. Recent studies have indicated that nongay identified men who have sex with men are more likely to have a female partner and have had unprotected vaginal sex [70]. Additionally, the majority of the trials were unblinded and relied on self-reported sexual behavior, which may result in social desirability bias [71]. However, several factors reduce the likelihood of this being an undue influence. First, the majority of interventions made efforts to reduce this effect by techniques such as ensuring confidentiality. Second, our findings with behavioral outcomes are similar to our outcomes from STDs, which corroborates the self-reported sex behavior findings. Future research should include biological assessment as well as self-reported sexual behavior, as this would increase our ability to evaluate the impact of interventions. Finally, all the trials had a comparison group and the assignment method was randomization, which reduced the likelihood that individual characteristics influenced the intervention effect. Our findings were also limited in that the majority of interventions (23/26) did not distinguish between primary and secondary partners in their analysis. Given that condom use has been found to differ between these types of partners [72], we recommend that future studies examine these partner-level differences both when assessing and reporting episodes of unprotected sex and condom use. Our meta-analysis was also limited by the fact that we only included individual-level and group-level interventions. There were only a few randomized community-level and structural-level interventions available in the literature [73–75]. However, given that many risk factors associated with HIV risk-taking in heterosexual African Americans are structural (e.g., poverty, access to care), future research should evaluate community-level and structural-level interventions when more RCTs become available.

Despite these limitations, our findings also pointed out several implications for future research. It is encouraging to see that several of the intervention studies [47,48] in our study were conducted with heterosexual African–American men, an understudied group [8,76]. Although studies targeting African–American adolescents were well represented in this study, few of these studies focused on younger adolescents. It is possible that the approach for HIV sex risk reduction among younger African–American adolescents may be different from older adolescents (e.g., interventions may emphasize delay of sexual initiation). We also did not identify any trials that examined prison populations, which have a high HIV prevalence compared with the general population [77].

Although our findings offer some evidence for factors associated with intervention efficacy in reducing HIV-risk sex behavior in heterosexual African Americans, to make a real impact on the HIV/AIDS epidemic, it is important to translate and disseminate evidence-based research. Some progress has been made in translating scientific-based knowledge into user-friendly intervention packages for dissemination through two CDC projects – Replicating Effective Programs (REP) and Diffusion of Effective Behavioral Interventions (DEBI). Several interventions for heterosexual African Americans have been packaged or are in the process of packaging (see PRS efficacy Web site http://www.cdc.gov/hiv/topics/research/prs/about.htm) [78]. However, translating research findings into effective interventions in real-world settings remains challenging. Although additional research needs to be conducted with regard to this translation, and some limitations to our methodology have been discussed, our findings for both behavioral and biological outcomes suggest that the behavioral strategies utilized in the included interventions can reduce the frequency of HIV risk behaviors in heterosexual African Americans. Thus, we suggest that the following efficacious intervention components identified in this study should be incorporated into the development of future interventions and further evaluated for effectiveness: cultural tailoring, social norms in promoting safer sex behavior, peer education, skills training on correct use of condoms and communication skills needed for negotiating safer sex, and multiple sessions and opportunities to practice skills. Future interventions that are aimed at African–American heterosexual participants should take the unique needs of the community into account.

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Acknowledgements

Other members of the HIV/AIDS Prevention Research Synthesis (PRS) Team who contributed to this review are (listed alphabetically) Julia Deluca, Jeffrey H. Herbst, Angela K. Horn, Linda Kay, Elizabeth Jacobs, Mary Mullins, Warren Passin, Sima Rama, Sekhar Thadiparthi, and Lev Zohrabyan.

L.A.D., G.E.K. and G.W.R. were supported in part by grants from the Office of AIDS, California Department of Health Services, and the Office of Minority Health, US. Department of Health and Human Services, and L.A.D. by NIH grant K08 MH 072380. The work of N.C. and C.M.L. was supported by the Prevention Research Branch, Division of HIV/AIDS Prevention, US. Centers for Disease Control and Prevention, and was not funded by any other organization.

All authors contributed to review concept and synthesis method. L.A.D. led the writing of Introduction and Discussion, scope screened studies, contacted authors for additional information, and abstracted qualitative data. N.C. led the writing of Methods and Results, abstracted qualitative and quantitative data, and conducted meta-analysis. C.M.L. abstracted qualitative and quantitative data, helped with quantitative analysis, and provided critical review of the manuscript. G.E.K. helped out screening studies, abstracted qualitative data, and provided critical review of the manuscript. G.W.R. provided critical review of the manuscript.

The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

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Keywords:

African–American; behavioral intervention; condom use; heterosexual; HIV/STD prevention meta-analysis; sexually transmitted diseases

© 2008 Lippincott Williams & Wilkins, Inc.

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