Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
You currently have no recent searches
Padilla, Sergioa; Gallego, Juan Ab; Masiá, Mara; Gutiérrez, Félixa
aInfectious Diseases Unit, Internal Medicine Department, Spain
bRadiology Department, Hospital General Universitario de Elche, Alicante, Spain.
Received 2 June, 2006
Accepted 21 June, 2006
We read with interest the report by Martinez et al.  about the potential role of sonography as a tool to quantify regional fat in HIV-infected patients. The authors stated that ‘concerning facial lipoatrophy, only sonography and three-dimensional surface laser imaging have been used to assess facial lipoatrophy’. They do not mention that computed tomography (CT) may also be suitable to quantitate facial fat.
In December 2004 we published our experience evaluating quantitative CT to measure facial fat in 61 consecutive HIV-infected patients receiving antiretroviral therapy . CT was performed on a Xpress/Gx helical scanner (Toshiba Medical Systems Europe, Zoetermeer, the Netherlands). The total right-side facial tissue area (TTA) and the facial adipose tissue area (ATA) were assessed by a single 7 mm slice obtained at the level of the upper lip. The ATA: TTA ratio was automatically calculated. The facial area was measured by drawing a line, which delineates the skin surface and continues on the external surface of the maxilla, ascending ramus of the mandible and posterior surface of parotid gland .
Patients with facial lipoatrophy had less malar skinfold, less facial ATA and less facial ATA: TTA ratio compared with patients without facial wasting. Moreover, a gradation in the measurements obtained by CT in association with the severity of lipoatrophy was found. The values of facial ATA of less than 2.34 cm2 and facial ATA: TTA ratio of less than 0.10 had a sensitivity of 71 and 74%, and a specificity of 71 and 67%, respectively, to diagnose facial fat loss. In our study, inter and intra-observer variability for CT scan measurements were acceptable, with the ATA: TTA ratio showing lower variation than the facial ATA.
As Martínez et al.  mentioned there is a great need for technology to quantitate facial fat in HIV-infected patients. HIV clinicians and researchers should know that a single-slice CT scan may allow facial fat quantification and may be useful to diagnose and monitor facial lipoatrophy.
© 2006 Lippincott Williams & Wilkins, Inc.
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at AIDS.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics