Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality
Wyatt, Christina Ma; Arons, Raymond Rc; Klotman, Paul Ea; Klotman, Mary Eb
From the aDivision of Nephrology
bDivision of Infectious Diseases, Department of Medicine, Mount Sinai Medical Center
cMailman School of Public Health, Columbia University, New York, USA.
Received 7 September, 2005
Revised 17 October, 2005
Accepted 27 October, 2005
Correspondence to Dr C.M. Wyatt, Division of Nephrology, Box 1243, Mount Sinai Medical Center, 1 Gustave L. Levy Place, New York 10029–6574, USA. E-mail: email@example.com
Background: Kidney disease is an increasingly important complication of HIV.
Objectives: To examine the incidence and predictors of acute renal failure before and after the introduction of HAART, and the impact of acute renal failure on in-hospital mortality in the post-HAART era.
Methods: Adults hospitalized in acute care hospitals in New York State during 1995 (pre-HAART) or 2003 (post-HAART) were identified from the state Planning and Research Cooperative System database. HIV status was defined by primary or secondary diagnosis code. The impact of HIV and HAART on the incidence of acute renal failure and mortality, and the impact of acute renal failure on mortality, was assessed using χ2 analysis and multivariate regression.
Results: There were 52 580 HIV-infected patients discharged from hospital in 1995 and 25 114 in 2003. Compared with uninfected patients, HIV-infected patients had an increased incidence of acute renal failure in both the pre-HAART [adjusted odds ratio (OR), 4.62; 95% confidence interval (CI), 4.30–4.95] and post-HAART eras (adjusted OR, 2.82; 95% CI, 2.66–2.99). In the post-HAART cohort, acute renal failure was associated with traditional predictors such as age, diabetes mellitus, and chronic kidney disease, as well as acute or chronic liver failure or hepatitis coinfection (P < 0.001 for all comparisons). Acute renal failure was associated with mortality among HIV-infected patients in the post-HAART era (OR, 5.83; 95% CI, 5.11–6.65).
Conclusions: Acute renal failure remains common among hospitalized patients with HIV and is associated with chronic kidney disease, liver disease, and increased mortality.
The introduction of HAART at the end of 1995 dramatically altered the course of HIV infection in communities with access to therapy, significantly reducing mortality and progression to AIDS [1–5]. Kidney, liver, and cardiac disease have emerged as important complications in HAART-treated patients, overtaking opportunistic infections as leading causes of death among HIV-infected patients in the United States . Patients with HIV are at risk for kidney disease related to HIV-associated nephropathy or immune complex disease [7–10], thrombotic microangiopathy [11–13], hepatitis B or C virus-related kidney disease [10,14–16], and medication toxicity [17–19].
Acute renal failure is a common complication in ambulatory HIV-infected patients treated with HAART and has recently been associated with AIDS, hepatitis C virus coinfection, and liver disease . Patients hospitalized with complications of HIV may also be at increased risk for acute renal failure related to volume depletion, hemodynamic stress, and the acute administration of nephrotoxic medications or radiocontrast. Acute renal failure is a strong predictor of in-hospital morbidity and mortality in the general population , and retrospective data from early in the AIDS epidemic suggest that the development of acute tubular necrosis is also predictive of mortality in HIV-infected patients [22–23]. The purpose of this study was to compare the incidence of acute renal failure in HIV-positive individuals before and after the introduction of HAART, and to describe the impact of acute renal failure on mortality in the HAART era.
Subjects and setting
The study included all adult patients who were discharged from acute care hospitals in New York State during 1995, the last year prior to the widespread introduction of HAART, and during 2003, the last year for which data are available in the HAART era. All data for this study were obtained from the New York State Department of Health Statewide Planning and Research Cooperative System (SPARCS) database, which records information on all hospital discharges. Data are submitted using form UB90, which combines demographic and clinical information with billing information on all patients discharged during the calendar year. Variables recorded in the SPARCS database include basic demographic data, diagnosis and procedure codes, diagnosis-related group, dates of admission and discharge, and patient disposition (death, release from hospital, etc.) at discharge. Diagnosis and procedure codes are based on the International Classification of Diseases, 9th Revision (ICD-9). To protect patient confidentiality, all requests for data are reviewed by a Data Protection Review Board. The administrative releasable dataset used for the current study contained no unique patient identifiers.
Main outcome measures
All patients with a primary or secondary diagnosis of HIV/AIDS were identified. Patients were excluded from this study if they were younger than 18 years of age. The presence of acute renal failure was determined by a diagnosis code 584, which identified a diagnosis of acute renal failure based on the clinical judgment of the treating physician. Renal replacement therapy (hemodialysis or hemofiltration) was determined based on procedure code. The specific indications for renal replacement therapy and the choice of modality were not reported in this database. In-hospital mortality was defined based on patient disposition at hospital discharge.
Demographic and clinical variables included in this study reflected those variables previously shown to be predictive of acute renal failure in the general population, including gender, age, diabetes, chronic kidney disease, and primary diagnosis. Analyses were also adjusted for the presence of acute or chronic liver disease or hepatitis coinfection, factors recently shown to be associated with acute renal failure in HIV-infected patients. Laboratory data and medication records were not available in this database.
All data analysis was performed using SAS statistical software (version 9.1.3; SAS Institute, Cary, North Carolina, USA). The primary outcome variables were acute renal failure and in-hospital mortality. Data were summarized as means ± SD for continuous variables, and as proportions for categorical variables. Univariate comparisons of demographics, comorbid conditions, acute renal failure, and in-hospital mortality were performed using χ2, ANOVA, and Student's t tests. Multivariable logistic regression was performed to determine the impact of HIV and acute renal failure on outcomes after adjusting for demographics, comorbid conditions, and primary diagnosis. The primary diagnosis was defined by diagnosis-related group and categorized as HIV-related, psychiatric/substance abuse, cardiovascular, liver, obstetrics–gynecology, malignancy, or other diagnosis. These classifications were based on the most prevalent diagnoses among HIV-infected patients in this cohort. To adjust for potential variability in patient population, diagnostic criteria, clinical practice, and billing procedures, a dichotomous variable was included in all models to identify whether or not the admission occurred at a New York State Department of Health- designated AIDS center. Because patient characteristics and event rates were anticipated to vary significantly between the two time periods, most analyses were performed separately for the HAART and pre-HAART cohorts. Reported P values were two sided, P < 0.05 indicating statistical significance.
Patient characteristics in 2003
During the 2003 calendar year, there were 2 035 961 adult hospital discharges in New York State, including 25 114 for patients with documented HIV infection. Baseline characteristics of patients with and without HIV infection are summarized in Table 1. Patients with HIV infection were significantly younger (44.2 versus 56.6 years; P < 0.001) and were more likely to be male (61.6 versus 40.8%; P < 0.001) and to report their race as black (49.0 versus 17.0%; P < 0.001). While comorbid diabetes mellitus was reported less often in patients with HIV infection, chronic kidney disease was significantly more common in HIV-infected patients. Viral hepatitis, cirrhosis, and acute hepatic failure were also reported more frequently in the setting of HIV infection, with a cumulative incidence of liver disease of 20.7% compared with 2.7% in patients without documented HIV infection (P < 0.001).
Patient characteristics in 1995
Among 2 061 084 adult hospital discharges in 1995, there were 52 580 for patients with documented HIV infection. Similar to comparisons with uninfected patients in 2003, HIV-infected patients were significantly younger, more likely to be male, and more likely to report their race as black (Table 1; P < 0.001 for all pairwise comparisons). The pattern of comorbidity was also similar in 1995, with less diabetes and more chronic kidney disease and liver disease among HIV-infected patients compared with uninfected patients. Among patients with HIV, significantly fewer hospitalizations were complicated by comorbid diabetes (4.4 versus 10.2%; P < 0.001) and liver disease (8.6 versus 20.7%; P < 0.001) in 1995 compared with 2003.
HIV infection as a predictor of acute renal failure and in-hospital mortality
Acute renal failure was reported significantly more often during hospitalizations for HIV-infected patients than for uninfected patients in both 2003 (6.0% versus 2.7%) and 1995 (2.9 versus 1.0%). Renal replacement therapy was prescribed in only 1% of discharges among patients with HIV in 2003, and in < 1% in 1995. After adjusting for demographics, comorbid conditions, primary diagnosis, and admission to a designated AIDS center, HIV infection remained associated with an increased risk of acute renal failure both in 2003 [odds ratio (OR), 2.82; 95% confidence interval (CI), 2.66–2.99] and in 1995 (OR, 4.62; 95% CI, 4.30–4.95). HIV infection was also associated with an increased adjusted risk of in-hospital mortality, both in 2003 (adjusted OR, 2.96; 95% CI, 2.79–3.14) and in 1995 (adjusted OR, 6.74; 95% CI, 6.48–7.01). In patients with HIV, acute renal failure was more common in 2003 than in 1995 (adjusted OR, 2.02; 95% CI, 1.86–2.18), while in-hospital mortality was predictably lower in the HAART era (adjusted OR, 0.49; 95% CI, 0.46–0.52).
Acute renal failure as a predictor of mortality in patients with HIV in the HAART era
Table 2 summarizes patient characteristics in 2003 for the 1516 hospitalizations complicated by acute renal failure among patients with HIV infection compared with those with no documented acute renal failure. Among HIV-infected patients, acute renal failure was associated with traditional risk factors for renal disease, including older age, black race, diabetes, and preexisting chronic kidney disease. In addition, hepatitis coinfection, cirrhosis, and acute hepatic failure were more commonly reported in hospitalizations complicated by acute renal failure (P < 0.001 for all comparisons in univariate analysis). Older age, male gender, diabetes, chronic kidney disease, and liver disease remained associated with acute renal failure in the adjusted analysis (Table 3).
Hospitalizations of HIV-infected patients that were complicated by acute renal failure were also complicated by much higher in-hospital mortality (27%) than seen in admissions of HIV-infected patients without acute renal failure (4.5%). After adjusting for demographics, comorbid conditions, primary diagnosis, and admission to a designated AIDS center, acute renal failure was associated with a nearly sixfold increase in in-hospital mortality among HIV-infected patients in 2003 (OR, 5.83; 95% CI, 5.11–6.65). Chronic kidney disease (OR, 1.97; 95% CI, 1.59–2.45) and acute or chronic liver disease (OR, 1.46; 95% CI, 1.30–1.65) were also independently associated with increased in-hospital mortality for HIV-positive patients in the adjusted analysis (Table 4).
The development of acute renal failure is a strong predictor of mortality in hospitalized patients , and kidney disease has emerged as a leading cause of death among HIV-infected patients in the HAART era . This study compared the incidence and predictors of acute renal failure and mortality before and after the widespread introduction of HAART, and described the impact of acute renal failure on mortality in a contemporary cohort of patients with HIV infection who were hospitalized in New York State. HIV infection was associated with an increased risk of acute renal failure and in-hospital mortality both before and after the widespread introduction of HAART. Among patients with HIV infection, acute renal failure was a strong predictor of in-hospital mortality in the HAART era. In addition, chronic kidney disease and acute or chronic liver disease were strongly associated with both acute renal failure and in-hospital mortality among patients with HIV, suggesting a need for more aggressive management of chronic kidney disease and hepatitis virus coinfection in the setting of HIV.
These findings must be interpreted in light of the limitations of an observational database. The diagnosis of acute renal failure was based on the clinical judgment and documentation of the treating physician, and laboratory data were not reported. Databases similar to the one used in this study have been shown to have high specificity but poor sensitivity for non-primary diagnoses and procedures . These databases are generally more sensitive for active conditions than for chronic comorbid conditions, but they may underestimate the incidence of acute renal failure as well as the burden of medical comorbidity. This type of misclassification bias typically results in diluted OR values rather than type I errors. In the absence of laboratory data or specific indications for the initiation of renal replacement therapy, it is also possible that acute renal failure was a marker of systemic disease and multiorgan failure. Further studies are needed to determine whether acute renal failure is an independent predictor of outcomes or merely an indicator of more critical illness. In addition, it was not possible to account fully for severity of HIV infection in the absence of parameters such as HIV viral load or CD4 cell count. Primary diagnosis was included in the adjusted analyses as an indication of whether the current admission was HIV related. Hospitalized patients with HIV infection may be more likely to have advanced disease; however, the results of this study are consistent with those recently reported by Franceschini et al.  in ambulatory patients with HIV infection.
The unexpected increase in incidence of reported acute renal failure in the HAART era may reflect a combination of factors related and unrelated to HIV. Because the incidence of reported acute renal failure increased among both HIV-infected patients and uninfected patients, it is possible that the apparent increase reflects differences in recognition and reporting of acute renal failure, or an increase in the acuity of hospital admissions in the later period. Nonetheless, the consistency between our results and those recently reported in ambulatory patients with HIV  suggests a true increase in the incidence of acute renal failure in the HAART era. This study attempted to adjust for the increasing burden of diabetes and liver disease in patients with HIV, but it is possible that both comorbid disease and medication nephrotoxicity play a more important role in the HAART era. Given the increasing prevalence of HIV-related end-stage renal disease and the continued growth of the HIV epidemic among susceptible African-Americans, it is projected that the prevalence of HIV-associated nephropathy will continue to increase in the United States . Because the diagnosis of underlying chronic kidney disease was based on physician recognition and reporting, it is likely that the prevalence of chronic kidney disease is underestimated in this database owing to the more indolent course of HIV-associated nephropathy in the HAART era. An increase in the prevalence of unrecognized chronic kidney disease could also predispose HIV-infected patients to acute renal failure. The SPARCS database does not include information on chronic medication use, but future studies should also investigate the potential impact of HAART or specific antiretroviral medications on the incidence of acute renal failure and chronic kidney disease in HIV-infected patients.
The results of this cohort study suggest that acute renal failure remains a common complication among hospitalized patients with HIV in the HAART era. Acute renal failure in patients with HIV is associated with traditional risk factors such as diabetes, advanced age, and chronic kidney disease, as well as both acute and chronic liver disease or hepatitis coinfection. With improved survival in the HAART era, chronic kidney and liver disease have emerged as important complications in patients with HIV . These data highlight the need to identify chronic kidney disease and hepatitis virus coinfection in the setting of HIV and to treat them aggressively. In addition, these results suggest that acute renal failure remains a strong predictor of mortality in the HAART era. Further prospective studies are needed to determine whether acute renal failure is an independent predictor of in-hospital mortality, or a marker of more critical systemic illness. In addition, future studies should investigate the impact of HAART or specific antiretroviral agents on the incidence of acute and chronic kidney disease in patients with HIV.
1. Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report. Atlanta, ga: Centers for Disease Control and Prevention; 2004.
2. Egger M, Hirschel B, Francioli P, Sudre P, Wirz M, Flepp M, et al
. Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: prospective multicentre study. Swiss HIV cohort Study. Br Med J 1997; 315:1194–1199.
3. Palella FJ, Delaney K, Moorman A, Loveless M, Fuhrer J, Satten G, et al
. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Study Investigators. N Engl J Med 1998; 338:853–860.
4. Pezzotti P, Napoli PA, Acciai S, Boros S, Urciuoli R, Lazzeri V, et al
. Increasing survival time after AIDS in Italy: the role of new combination antiretroviral therapies. Tuscany AIDS Study Group. AIDS 1999; 13:249–255.
5. Porta D, Rapiti E, Forastiere F, Pezzotti P, Perucci CA. Changes in survival among people with AIDS in Lazio, Italy from 1993 to 1998. AIDS 1999; 13:2125–2131.
6. Selik RM, Byers RH Jr, Dworkin MS. Trends in diseases reported on US death certificates that mentioned HIV infection, 1987–1999. J Acquir Immune Defic Syndr 2002; 29:378–387.
7. Gardenschwartz MH, Lerner CW, Seligson GR, Zabetakis PM, Rotterdam H, Tapper ML, et al
. Renal disease in patients with AIDS: a clinicopathologic study. Clin Nephrol 1984; 21:197–204.
8. Pardo V, Aldana M, Colton RM, Fischl MA, Jaffe D, Moskowitz L, et al
. Glomerular lesions in the acquired immunodeficiency syndrome. Ann Intern Med 1984; 101:429–434.
9. Rao TK, Filippone EJ, Nicastri AD, Landesman SH, Frank E, Chen CK, et al
. Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N Engl J Med 1984; 310:669–673.
10. D'Agati V, Appel GB. Renal pathology of human immunodeficiency virus infection. Semin Nephrol 1998; 18:406–421.
11. Boccia RV, Gelmann EP, Baker CC, Marti G, Longo DL. A hemolytic uremic syndrome with acquired immunodeficiency syndrome. Ann Intern Med 1984; 101:716–717.
12. Thompson CE, Damon LE, Ries CA, Linker CA. Thrombotic microangiopathies in the 1980s: clinical features, response to treatment, and the impact of the human deficiency virus epidemic. Blood 1992; 80:1890–1895.
13. Bachmeyer C, Blanche P, Sereni D, Salmon D, Grateau D, Dreyfus F, et al
. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome in HIV-infected patients. AIDS 1995; 9:532–533.
14. Lai KN, Li PK, Lui SF, Au TC, Tam JS, Tong KL, et al
. Membranous nephropathy related to hepatitis B virus in adults. N Engl J Med 1991; 324:1457–1463.
15. Han SH. Extrahepatic manifestations of chronic hepatitis B. Clin Liver Dis 2004; 8:403–418.
16. Meyers CM, Seef LB, Stehman-Breen CO, Hoofnagle JH. Hepatitis C and renal disease: an update. Am J Kidney Dis 2003; 42:631–657.
17. Brodie SB, Keller MJ, Ewenstein BM, Sax PE. Variation in incidence of indinavir-associated nephrolithiasis among HIV-positive patients. AIDS 1998; 12:2433–2437.
18. Izzedine H, Launay-Vacher V, Deray G. Anti-retroviral drugs and the kidney: dosage adjustment and renal tolerance. Curr Pharm Des 2004; 10:4071–4079.
19. Barrios A, Garcia-Benayas T, Gonzalez-Lahoz J, Soriano V. Tenofovir-associated nephrotoxicity in HIV-infected patients. AIDS 2004; 18:960–963.
20. Franceschini N, Napravnik S, Eron JJ, Szczech LA, Finn WF. Incidence and etiology of acute renal failure among ambulatory HIV-infected patients. Kidney Int 2005; 67:1526–1531.
21. Nash K, Hafeez A, Hou S. Hospital-acquired renal failure. Am J Kidney Dis 2002; 39:930–936.
22. Rao TK, Friedman EA. Outcome of severe acute renal failure in patients with acquired immunodeficiency syndrome. Am J Kidney Dis 1995; 25:390–398.
23. Peraldi MN, Maslo C, Akposso K, Mougenot B, Rondeau E, Sraer JD. Acute renal failure in the course of HIV infection: a single-institution retrospective study of ninety-two patients and sixty renal biopsies. Nephrol Dial Transplant 1999; 14:1578–1585.
24. Longenecker JC, Coresh J, Klag MJ, Levy AS, Martin AA, Fink NE, et al
. Validation of comorbid conditions on the end-stage renal disease medical evidence form: the CHOICE study. Choices for Healthy Outcomes in Caring for ESRD. J Am Soc Nephrol 2000; 11:520–529.
25. Schwartz EJ, Szczech LA, Ross MJ, Klotman ME, Winston JA, Klotman PE. Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease. J Am Soc Nephrol 2005; 16:2412–2420.
This article has been cited 32 time(s).
Mayo Clinic Proceedings
HIV-1 infection and the kidney: An evolving challenge in HIV medicine
Mayo Clinic Proceedings, 82(9):
British Journal of Hospital Medicine
HIV and the kidney
British Journal of Hospital Medicine, 69(3):
Renal disease in patients with HIV infection - Epidemiology, pathogenesis and management
Clinical Infectious DiseasesKidney Disease in Patients with HIV Infection and AIDSClinical Infectious Diseases
Enfermedades Infecciosas Y Microbiologia ClinicaAssessment and management of kidney disease in the HIV-1-infected patient. A practical reviewEnfermedades Infecciosas Y Microbiologia Clinica
The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years
Brazilian Journal of Medical and Biological Research
Hypomagnesemia is a risk factor for nonrecovery of renal function and mortality in AIDS patients with acute kidney injury
Brazilian Journal of Medical and Biological Research, 43(3):
American Journal of MedicineHIV-associated nephropathy in the era of antiretroviral therapyAmerican Journal of Medicine
Seminars in NephrologyEpidemiology of acute kidney injury in AfricaSeminars in Nephrology
Clinical Infectious DiseasesCauses of Death in HIV-1-Infected Patients Treated with Antiretroviral Therapy, 1996-2006: Collaborative Analysis of 13 HIV Cohort StudiesClinical Infectious Diseases
Annals of Emergency MedicineCare of the HIV-positive patient in the emergency department in the era of highly active antiretroviral therapyAnnals of Emergency Medicine
Critical CareAcute renal failure in critically ill HIV-infected patientsCritical Care
Rates of hospitalizations and associated diagnoses in a large multisite cohort of HIV patients in the United States, 1994-2005
Seminars in NephrologyAcute Kidney Injury in HIV-Infected PatientsSeminars in Nephrology
Nature Reviews NephrologyThe nephrotoxic effects of HAARTNature Reviews Nephrology
Clinical Infectious DiseasesHIV care and the incidence of acute renal failureClinical Infectious Diseases
Expert Opinion on Drug SafetyNephrotoxicity associated with antiretroviral therapy in HIV-infected patientsExpert Opinion on Drug Safety
Emergency Medicine Clinics of North AmericaRenal and Urologic Emergencies in the HIV-infected PatientEmergency Medicine Clinics of North America
Journal of Viral HepatitisReduced glomerular filtration rate but sustained virologic response in HIV/hepatitis B co-infected individuals on long-term tenofovirJournal of Viral Hepatitis
Hiv MedicinePrevalence and factors associated with renal impairment in HIV-infected patients, ANRS C03 Aquitaine Cohort, FranceHiv Medicine
Clinical Journal of the American Society of NephrologyRenal Vulnerability to Drug ToxicityClinical Journal of the American Society of Nephrology
Enfermedades Infecciosas Y Microbiologia ClinicaHypertension, HIV infection, and highly active antiretroviric therapyEnfermedades Infecciosas Y Microbiologia Clinica
Hiv MedicineAcute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administrationHiv Medicine
Clinics in Chest MedicineCritical Care of Persons Infected with the Human Immunodeficiency VirusClinics in Chest Medicine
Bmc NephrologyLong-term risk of mortality for acute kidney injury in HIV-infected patients: a cohort analysisBmc Nephrology
Nature Reviews NephrologyCommunity-acquired acute kidney injury in tropical countriesNature Reviews Nephrology
Nephrology Dialysis TransplantationThe significance of antiretroviral-associated acute kidney injury in a cohort of ambulatory human immunodeficiency virus-infected patientsNephrology Dialysis Transplantation
AIDSThe nephrologist in the HAART eraAIDS
Current Opinion in Critical CareAcute kidney injury in patients with human immunodeficiency virus infectionCurrent Opinion in Critical Care
Current Opinion in Infectious DiseasesRecent developments in HIV and the kidneyCurrent Opinion in Infectious Diseases
acute renal failure; HIV; hospitalisation; mortality; odds ratio
© 2006 Lippincott Williams & Wilkins, Inc.
Highlight selected keywords in the article text.