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Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naïve patients

Monforte, Antonella d'Arminioa; Lepri, Alessandro Cozzib; Rezza, Giovannic; Pezzotti, Patrizioc; Antinori, Andread; Phillips, Andrew N.b; Angarano, Gioacchinoe; Colangeli, Vincenzof; Luca, Andrea Deg; Ippolito, Giusepped; Caggese, Lilianah; Soscia, Fabrizioi; Filice, Gaetanoj; Gritti, Francescok; Narciso, Pasqualed; Tirelli, Umbertol; Moroni, Mauro*; for the I.CO.N.A. Study Group

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Author Information

From the aInstitute of Infectious and Tropical Diseases, University of Milan, Milan, Italy, the bRoyal Free Centre for HIV Medicine, Royal Free & Universiy College Medical School, London, UK, the cIstituto Superiore di Sanità, Rome, the dIRCCS L. Spallanzani, Rome, the eInstitute of Infectious Diseases, University of Bari, Bari, the fInstitute of Infectious Diseases, University of Bologna, Bologna, the gClinic of Infectious Diseases, Cattolica University, Rome, the hDepartment of Infectious Diseases, Niguarda Hospital, Milan, the iAIDS Center, Latina Hospital, Latina, the jInstitute of Infectious Diseases, University of Pavia, Pavia, the kDepartment of Infectious Diseases, Maggiore Hospital, Bologna and the lOncology Center of Aviano, Pordenone, Italy. *See Appendix.

Sponsorship: The I.CO.N.A. network is supported by an unrestricted educational grant provided by Glaxo-Wellcome Italy.

Correspondence to Antonella d'Arminio Monforte, Institute of Infectious and Tropical Diseases, University of Milan, L. Sacco Hospital, via GB Grassi, 74, 20157 Milan, Italy. E-mail:

Received: 16 March 1999;

revised: 21 June 1999; accepted: 23 November 1999.

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Objective: To evaluate the frequency of discontinuation of the first highly active antiretroviral regimen (HAART) and the factors predictive of discontinuing for toxicity and failure in a population-based cohort of HIV-positive individuals in Italy, naïve from antiretrovirals at enrolment.

Methods: The study population consisted of individuals who initiated HAART and had at least one follow-up visit. The primary end-points were discontinuation of any component of HAART for drug toxicity and discontinuation for failure. Survival analyses were performed to identify predictive factors for reaching the two end-points.

Results: Eight hundred and sixty-two individuals initiated HAART; in 727 of them (84.3%) this consisted of two nucleoside reverse transcriptase inhibitors (NRTI) and one protease inhibitor (PI). Over a median follow-up of 45 weeks, 312 patients (36.2%) discontinued therapy: 182 (21.1%) discontinued due to toxicity, 44 (5.1%) due to failure. The probability of discontinuing HAART at 1 year was 25.5% [95% confidence interval (CI), 21.9–28.9] due to toxicity and 7.6% (95% CI, 4.9–10.3) due to failure. Independent factors associated with discontinuation for toxicity were: gender [relative hazard (RH) = 0.51; 95% CI, 0.32–0.80 for men versus women], type of treatment (indinavir-containing regimens, RH = 1.94; 95% CI, 1.10–3.41 and ritonavir-containing regimens, RH = 3.83; 95% CI, 2.09–7.03 versus hard-gell saquinavir) and time spent on treatment (RH = 0.89; 95% CI, 0.80–0.98 for each additional month). Discontinuation due to failure was independently associated with the most recent HIV-RNA (RH = 3.20; 95% CI, 1.74–5.88 for log10 copies/ml higher), and with type of treatment (indinavir-containing regimens, RH = 0.21; 95% CI, 0.06–0.78 and ritonavir-containing regimens, RH = 0.23; 95% CI, 0.04–1.26 versus hard-gell saquinavir).

Conclusions: If the current HAART regimen caused no toxicity, less than 10% of naïve patients discontinue their first HAART regimen because of failure after 1 year from starting therapy.

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Highly active antiretroviral therapy (HAART) is effective both in reducing plasma viral load and in prolonging AIDS-free survival, as demonstrated by various clinical trials [1–4]. Since HAART was introduced in clinical practice, AIDS-related events, hospitalizations and deaths have decreased in various clinical settings [5–7].

However, HAART has two main drawbacks: toxicity and low compliance. Although the frequency and the effects of toxicity have been assessed in clinical trials [2–4], they have not been thoroughly evaluated in clinical settings. Low compliance, which is often a consequence of persistent side effects, may lead to sub-optimal therapy or to therapy discontinuation and ultimately to treatment failure [8].

According to population-based studies on HAART conducted among unselected pre-treated patients, virological failure occurs in almost 50% of patients after 6–12 months of therapy [9,10], and within 8 months approximately 25% of patients discontinue the initial HAART regimen due to failure, toxicity or non-compliance [11,12]. Van Roon et al. [13] studied the incidence of discontinuation of HAART and its determinants in a clinical cohort of mixed drug-naïve and -experienced patients who mainly started saquinavir-containing regimens. They found that 25% of patients discontinued HAART by 1 year from starting therapy. Main predictors of discontinuing HAART were baseline CD4 cell count and being naïve at the time of starting HAART. However, none of these studies have investigated the determinants of discontinuation of HAART according to the reason for discontinuing (collected from clinicians in real time) in an observational cohort of antiretroviral-naïve patients starting their first HAART regimen.

Although an increasing number of new drugs have been licensed in the last few years, when treatment fails, the clinical options are limited by the existence of cross-resistance among drugs of the same class; options are also limited in cases of toxicity, since various types of toxicity are generally common to several antiretroviral drugs [14].

Based on these considerations, we decided to determine the frequency of discontinuation of the first HAART regimen and to study the factors associated with discontinuation because of toxicity or failure in a population of HIV-positive antiretroviral-naïve patients starting their first HAART regimen in Italy.

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Study population and methods

The study population was that of the Italian Cohort of Antiretroviral-Naïve Patients (I.CO.N.A.) study which between March 1997 and 31 May 1999 has recruited 3586 patients from 65 infectious disease wards in Italy [15]. All patients must be antiretroviral-naïve at the time of enrolment, regardless of the reason for which they had never been treated. The present study only analysed those patients who, once enrolled in the I.CO.N.A. study, began an antiretroviral regimen with at least three antiretroviral drugs (i.e., HAART) and who underwent at least one follow-up visit after starting therapy. Data from all patients of the I.CO.N.A. study are registered in a data-base running via internet [16] which includes demographic, immunological, virological, clinical and therapeutic parameters. All patients are assumed to receive the recommended doses of antiretroviral drugs. All events are registered in the data-base over the follow-up (i.e., all CD4 cell count and HIV RNA measurements, clinical events, changes in therapy or prophylactic treatment, hospitalizations, and death); in their absence, a follow-up visit is scheduled at least every 6 months. When a patient discontinues therapy, regardless of whether or not he/she switches to another regimen, clinicians are asked to report the reason for discontinuing. A coded computer form is provided in which reasons for discontinuing are categorized as follows: immunological failure, virological failure, clinical failure, toxicity based on laboratory data, gastrointestinal intolerance, hypersensitivity, other side effects/symptoms, lack of compliance, patient's decision, changes in international guidelines, clinical contraindications, and `other reasons'. The clinician is asked to choose only one of these reasons.

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Statistical analysis

Standard survival analysis by means of Kaplan–Meier estimates and Cox proportional hazards model was performed. Kaplan–Meier plots have been used to describe the probability of discontinuing HAART by a certain time from starting therapy and the Cox model to determine the predictors of discontinuing HAART. We considered two primary end-points for this analysis: (i) discontinuing HAART for reasons associated with drug-intolerance (i.e., toxicity based on laboratory data, gastrointestinal intolerance, hypersensitivity, other side effects/symptoms) and (ii) discontinuing HAART for clinical decisions associated with poor virological/immunological response or clinical outcome. The date of discontinuation was defined as the first time one of the drugs in the specific combination was terminated; the reason for discontinuing this drug was defined as the reason associated with discontinuing the prescribed treatment combination. `Time zero' of the analysis was the date of starting HAART. When we investigated the association between `time spent on treatment' and the defined end-points, time zero was the date of first clinical follow-up.

Thus survival time was the time since the first clinical follow-up and patients were not considered to be at risk of discontinuing until this time was greater or equal to the time of initiating HAART. This was done so `time on treatment' did not coincide with the survival time and could be included in the model as a covariate. Follow-up times of patients who never discontinued HAART were censored at their last clinical visit; this was done because, although discontinuation should be reported between clinical visits, some delay in reporting such information generally occurs. For the same reason, patients with no clinical visits after the date of starting therapy were excluded from the analysis. Follow-up times of patients who discontinued HAART for reasons other than the end-points of interest were censored at the time of discontinuation under the assumption that the probability of discontinuing for toxicity was totally unrelated to that of discontinuing for failure. This assumption was checked by repeating the analysis with end-point toxicity only on patients whose viral load at the time of discontinuing was below 500 copies/ml. A fixed covariate was fitted for baseline CD4 cell count and HIV-RNA, whereas to investigate whether the most recent value of these markers was affecting the probability of discontinuation of HAART, a time-updated covariate was included in the model. To control for the potential confounding effect of infectious disease ward a stratified proportional hazards model has been fitted. When investigating the determinants of discontinuation of HAART only 717 patients who started two nucleoside reverse transcriptase inhibitors (NRTI) and one of the following protease inhibitors: indinavir, ritonavir or hard-gell saquinavir were included in the analysis.

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A total of 862 patients were included in this analysis. The baseline characteristics of the patients are shown in Table 1. Of this total, 632 (73.3%) patients were males, 349 (40.5%) were intravenous drug users, 183 (21.2%) were infected by the homosexual route, 273 (31.7%) by the heterosexual route and 57 (6.6%) by other or unknown routes. Most patients (68.5%) were asymptomatic, i.e. in group A of the US Centers for Disease Control and Prevention (CDC) [17]. Median CD4+ cell count at HAART initiation was 309 × 106 cells/l (range, 1–1294), median HIV-RNA was 4.78 log10 copies/ml (range, 2.75–6.74). Clinical markers have been measured approximately every 3 months: 28 patients (3.2%) had one measurement, 102 (11.8%) had two measurements, 164 (19.0%) had three measurements and 568 (65.9%) had four or more measurements. A total of 727 (83.9%) patients initiated two NRTI plus one protease inhibitor (PI), 15 (1.7%) initiated three NRTI, 33 (3.8%) initiated two NRTI plus one non-nucleoside reverse transcriptase inhibitor (NNRTI), four (0.5%) initiated three other drugs and 83 (9.6%) initiated four or more drugs. Zidovudine and lamivudine were the most used NRTI (82.1 and 66.2% of patients, respectively), stavudine was started by 23.7% of patients and didanosine by 21.3%. Among the 727 patients starting two NRTI and one PI, indinavir was used in 394 patients (54.2%), hard-gell saquinavir in 213 (29.3%), ritonavir in 110 (15.1%) and nelfinavir in 10 (1.4%). Among the 33 patients starting two NRTI and one NNRTI, nevirapine was the most commonly used (30 patients, 90.9%), efavirenz was used in two patients and delavirdine in one patient. The most frequent combination was zidovudine + lamivudine + indinavir (274 patients; 37.7%).

Table 1
Table 1
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Over a median follow-up of 45 weeks (range, 1–102), a total of 312 (36.2%) patients discontinued their initial HAART regimen: 182 (21.1%) discontinued because of toxicity, 44 (5.1%) discontinued because of failure, 61 (7.1%) because of non-adherence and 25 (2.9%) for other reasons. Specific causes of discontinuation within this broad classification are shown on Table 2. The main types of toxicity were gastrointestinal intolerance and general side effects/symptoms which accounted for 26.3 and 18.9% of the total discontinuations.

Table 2
Table 2
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Regarding the reasons for discontinuation for failure, viral load (4.2%), rather than CD4 cell count (0.6%), was the most common reason that clinicians decided to discontinue the prescribed treatment; discontinuation due to clinical failure was also infrequent (0.3%).

The time to discontinuation varied according to the reason of discontinuation. Discontinuations because of toxicity occurred earlier (median = 84 days) than discontinuations due to failure (median = 270 days). Discontinuations because of gastrointestinal intolerance and general side effects/symptoms occurred after a median of 66 and 87 days, respectively. Patients who discontinued HAART because of virological failure did so after a median of 273 days.

The probability of discontinuation because of toxicity and because of failure by a certain time from starting HAART were estimated using Kaplan–Meier analysis (Fig. 1). After 1 year from starting HAART, 25.5% of patients [95% confidence interval (CI), 21.9–28.9] discontinued the initial HAART treatment because of toxicity, whereas 7.6% (95% CI, 4.9–10.3) of patients discontinued because of failure.

Fig. 1
Fig. 1
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Figure 2 shows the probability of discontinuing because of toxicity according to the protease inhibitor started within the group of patients who started two NRTI and one protease inhibitor. It is clear from this plot that discontinuations because of toxicity in patients receiving ritonavir-containing regimens occurred earlier and more frequently compared with patients on indinavir- and saquinavir-containing regimens (log-rank P  = 0.0001).

Fig. 2
Fig. 2
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Crude and adjusted relative hazards for therapy discontinuation due to toxicity and to failure, from fitting a Cox regression model stratified for clinical centre, are shown in Table 3. Age, weight, presence of markers for hepatitis B virus co-infection and hepatitis C virus co-infection, baseline CD4 cell count, baseline HIV-RNA, CDC classification, modality of HIV transmission failed to show any significant association with the probability of discontinuing treatment, whatever the reason (data not shown). By contrast, gender, time spent on treatment, and type of regimen started were independently associated with the probability of discontinuing HAART because of toxicity. Specifically, men were 57% less likely than women to discontinue for toxicity [relative hazard (RH) = 0.43; 95% CI, 0.28–0.66;P  = 0.0002] for a given HIV transmission route, CD4 cell count and viral load (most recent value), time since treatment was started, and type of treatment. Results were similar after further adjusting for patients' weight at the time of receiving HAART (data not shown). Patients given indinavir- and ritonavir-containing regimens were more likely to discontinue HAART for toxicity than patients given saquinavir-containing regimens (RH = 1.63; 95% CI, 0.96–2.77;P  = 0.07 for indinavir and RH = 3.66; 95% CI, 2.07–6.47;P  = 0.0001 for ritonavir versus saquinavir). Time spent on treatment was also an important predictor of discontinuing for toxicity, the probability of discontinuation decreasing with longer periods of treatment (RH = 0.92 per additional month spent on treatment, 95% CI, 0.85–1.00;P  = 0.05). Results were similar when the analyses were repeated including only patients who had a viral load below 500 copies/ml at the time of discontinuation (data not shown).

Table 3
Table 3
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Type of treatment and the most recent HIV-RNA showed a significant independent association with the probability of discontinuing HAART for failure. Regimens containing indinavir were associated with a reduced probability of discontinuing because of failure in comparison with saquinavir-containing regimens, for a given viral load and CD4 cell count, CDC stage classification, and HIV transmission route (RH = 0.24; 95% CI, 0.08–0.73;P  = 0.01). The comparison with ritonavir-containing regimens was marginally non-significant (RH = 0.20; 95% CI, 0.03–1.16;P  = 0.07). Interestingly, higher CD4 cell count were associated with a decreased probability of discontinuing HAART because of failure in the univariate analysis but this association was no longer significant after controlling for the other covariates considered.

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The I.CO.N.A. study [15] provides unique data for estimating the proportion of HIV-positive antiretroviral naïve patients who discontinue their first HAART treatment and for identifying characteristics associated with discontinuation in routine clinical practice. Moreover, the `real-life' allocation to different HAART regimens and the high proportion of women allow the association between type of regimen and gender and the risk of therapy discontinuation to be evaluated.

With respect to the specific treatment regimens, it must be considered that the I.CO.N.A. cohort still mainly consists of patients recruited in 1997, the year in which protease inhibitors became available in Italy and in which HAART began to be recommended as the first regimen for compliant patients [18].

To date, discontinuation has not been addressed as a primary end-point in clinical trials, which generally evaluate treatment efficacy with an intention-to-treat approach, considering drop-outs as failures, and consequently penalize more aggressive, more toxic combinations. Nevertheless, the results of different clinical trials seem to indicate that the frequency of discontinuations due to toxicity depends on the trial, on the duration of follow-up, and on the tested combination. Among patients receiving indinavir, 1-4% have been reported to discontinue for toxicity, with no differences when compared with double combinations, in studies with follow-up periods ranging from 38 to 100 weeks [1,3]. In the trial by Cameron et al.[2], over a median of 29 weeks, a higher proportion of patients receiving ritonavir discontinued for toxicity compared to those receiving less potent regimens (21 versus 8%). In another study, approximately 5% of patients receiving hard-gell saquinavir discontinued for toxicity over a median of 24 weeks, with no differences with double combination therapy [4].

A key result of this observational study is that 36% of the 862 patients studied discontinued their first antiretroviral regimen in a median follow-up of 45 weeks, a proportion for the most part higher than those reported in clinical trials. Overall, toxicity, which mainly occurred within the first 3 months, was implicated in about 58% (182 of 312) of the discontinuations, whereas failure, occurring later, was implicated only in about 14% (44 of 312). The more frequent and earlier occurrence of discontinuations for toxicity were expected, since long-term toxicity, especially that believed to be associated with protease inhibitors [19], could not be evaluated because of the relatively brief follow-up period. These results are remarkably similar to those of a clinical survey conducted in a large clinic in the UK [12]. The Kaplan–Meier estimates of time to discontinuation due to failure, since patients' follow-up were censored if they discontinued for other reasons, can be interpreted as the proportion of patients who discontinue their first regimen in an ideal world where these drugs had no toxic effects. Thus, interestingly, less than 10% of antiretroviral-naïve patients would discontinue their first HAART regimen because of failure by 1 year from starting therapy if they could perfectly tolerate their regimen (Fig. 1).

Although it is well known that patients are more strictly observed in clinical trials than in general practice, the discrepancies are greater than expected. However, large hospital-based cohorts such as ours provide a better source for estimating the rate of therapy discontinuation, in that they are more representative of patients seen in routine clinical practice. Furthermore, previous studies conducted among observational cohorts of HIV-infected patients have reported higher rates of discontinuation and failure than those observed in clinical trials [9–12]. However, none of these studies examined the determinants of discontinuation of HAART according to the reason in a population of previously antiretroviral-naïve patients.

Non-adherence was a cause of therapy discontinuation in approximately 7% of cases. This rate is lower than the rates observed in other cohorts of unselected patients and in controlled clinical trials [20,21]. Given that we only considered those cases of non-adherence that were related to drug-taking behaviour, the true prevalence of erratic adherence may have been underestimated. This estimate, in fact, could have been higher if detected by adequate tools, such as self-reporting or objective measurements. It is also conceivable that patients initiating a first HAART treatment may be more likely to adhere than patients with a history of heavy treatment, and that clinicians, in a setting where medical care is free of charge, may correctly identify those patients at risk of low adherence and assign them to a non-PI regimen. Finally, since our study did not include any measures for confirming compliance, some of the discontinuations primarily due to non-compliance may have been classified as virological failure, due to co-existing rebound in viral load, or other reasons.

Another important finding of this paper is that women were twice as likely as men, in the adjusted analysis, to discontinue HAART due to toxicity. Clinical trials are generally performed on men and thus do not address this issue; an observational study similar to the present one showed that women were more likely to be excluded from the analysis of viral load because they discontinued double combination regimens or HAART more frequently than men [22]. Discontinuation due to toxicity was associated with the specific treatment combination started. Both indinavir- and ritonavir-containing regimens were associated with a higher risk of toxicity events compared with saquinavir-containing regimens. In particular toxicity events appeared to occur earlier and more frequently in patients who received ritonavir (Fig. 2). In the multivariable Cox model, the risk of discontinuation for toxicity was more than three times higher for patients given ritonavir and about 60% higher for patients given indinavir, in comparison with patients given saquinavir. However, since patients were not randomly allocated to the different regimens, these findings need to be interpreted with caution [23,24]. Nonetheless, ritonavir is known to be poorly tolerated, particularly as a result of gastrointestinal problems, and this may lead to poor compliance [11]. In mid-1998 ritonavir tablets were no longer available and patients on ritonavir-containing regimens were switched to the syrup formulation of ritonavir. The well-known bad taste of the syrup may have increased the chance of discontinuing these regimens because of non-adherence (e.g. patients' decision) but we controlled for this in the analysis by censoring follow-up times at the time of discontinuations for reasons other than the end-points of interest. Results are more difficult to interpret for indinavir, which, as already mentioned, is generally associated with a very low rate of severe adverse events; however, the association was marginally non-significant (P  = 0.07). The first months of treatment are crucial, as the risk of discontinuing because of toxicity decreases by 8% with each month on therapy. Again, it must be emphasized that this study, due to the short follow-up, currently lacks the power to evaluate chronic long-term toxicity. Surprisingly, even if patients with a high CD4 cell count are generally believed to tolerate drugs better than those with a low CD4 cell count, neither baseline nor most recent CD4 cell count showed a statistically significant association with discontinuing for toxicity.

The relatively good clinical conditions of the cohort at baseline (68% of patients in CDC stage A) and the short follow-up can explain the low rate of discontinuations due to clinical failure (less than 1%) over a median 45-week period of therapy. As expected, virological failure was the most common cause of therapy failure. In the multivariable Cox model, indinavir-containing regimens were associated with a reduced risk of discontinuation due to failure compared with saquinavir-containing regimens, which is consistent with the results of clinical trials and other similar observational studies [1,3,11,12]. Again, these results need to be taken with caution since it is not a randomized comparison. However, the low bioavailability of hard-gell saquinavir is well known as it has now been replaced by the soft-gell formulation. The result that the most recent HIV-RNA is predictive of discontinuation due to failure is not surprising and provides evidence that the classification of the reason of discontinuation given by the clinicians is reliable. The baseline HIV RNA level showed no statistical association with the outcome. This in contrast with the results of other studies showing that initial viral load at the time of starting therapy increases the chance of incomplete virological suppression upon initiation of HAART [9,10,25]. However in these studies a quantitative measure (such as, for example, viral load ≤ 500 copies/ml) was used to define the endpoint of the analysis. Furthermore, only 44 patients discontinued HAART because of failure and it is possible that the association with baseline viral load was not significant simply because of a lack of statistical power. Similarly, in the multivariate analysis, baseline CD4 cell count was not associated with the probability of discontinuing HAART because of failure, which is apparently inconsistent with the results of other studies that investigated the value of CD4 cell count in predicting virological response [10,25]. However, the univariate analysis carried strong evidence for an association, patients with higher CD4 cell count being at a lower chance of discontinuing due to failure.

Some aspects of the statistical analysis performed need to be discussed before interpreting the results and drawing final conclusions. First, survival analyses were conducted under the assumption that the probability of discontinuation for toxicity is completely unrelated to the probability of discontinuing for failure. Obviously, this assumption may not be entirely valid, and the results could be affected by a bias due to informative censoring [26]. However, the analysis for studying the factors associated with discontinuing for toxicity was repeated, including only patients who had a viral load below 500 copies/ml at the time of discontinuation; this analysis provided very similar results (data not shown), suggesting that, if this bias exists, it is probably small. A possible limitation of the study is that I.CO.N.A. includes patients from 65 different infectious diseases wards, and the way in which the individual wards determined the single reason for discontinuation in cases of concomitant reasons may have varied. However, this bias has been partially corrected by close central monitoring of all data; moreover, the potential confounding effect of the individual wards has been controlled for in the analyses.

In conclusion, patients receiving indinavir- and ritonavir-containing HAART regimens, were at lower chance of discontinuing HAART because of failure but also at higher risk of discontinuing because of toxicity compared with those receiving hard-gell saquinavir. Continuation of initial HAART regimen in antiretroviral-naïve patients is crucial for maintaining long-term viral suppression. Recent international guidelines because of the problems of intolerance and toxicity associated with PI-containing regimens indicate HAART regimens including two NRTI and one NNRTI as a viable alternative [27]. However, the lack of long-term data on NNRTI and clinical end-points makes PI-containing regimes the safer choice at present and continued monitoring of toxicity in patients (especially women) receiving indinavir- and ritonavir-containing HAART regimes recommended. If the current HAART regimen caused no toxicity, less than 10% of naïve patients discontinue their initial treatment because of failure after 1 year from starting therapy.

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The members of I.CO.N.A. Group are: Italy: Ancona: M Montroni, G Scalise, A Costantini, MS Del Prete. Aviano (PN): U Tirelli, G Nasti. Bari: G Angarano (Scientific Committee), LM Perulli. Bergamo: F Suter, F Maggiolo. Bologna: F Chiodo (Scientific Committee), FM Gritti, V Colangeli, C Fiorini, L Guerra. Brescia: G Carosi (Scientific Committee), GP Cadco, F Castelli, C Minardi, D Vangi. Busto Arsizio: S Caprioli, G Migliorino. Cagliari: PE Manconi, P Piano. Catanzaro: T Ferraro, L Cosco. Chieti: E Pizzigallo, F Ricci. Como: GM Vigevani, L Pusterla. Cremona: G Carnevale, A Pan. Cuggiono: P Viganò, GC Ghiselli. Ferrara: F Ghinelli, L Sighinolfi. Firenze: F Leoncini, F Mazzotta, S Ambu, S Lo Caputo. Foggia: B Grisorio, S Ferrara. Galatina (LE): P Grima, P Tundo. Genova: G Pagano, N Piersantelli, A Alessandrini, R Piscopo. Grosseto: M Toti, Chigiotti. Latina: F Soscia, L Tacconi. Lecco: A Orani, G Castaldo. Lucca: A Scasso, A Vincenti. Mantova: A Scalzini, F Alessi. Milano: M Moroni (Study Coordinator), A Lazzarin (Scientific Committee), A Cargnel, F Milazzo, L Caggese, A d'Arminio Monforte, V Testori, F Delfanti, B Carini, B Adriani, S Garavaglia, C Moioli. Modena: R Esposito, C Mussini. Napoli: N Abrescia, A Chirianni, O Perrella, M Piazza, L Boccia, V Montesarchio, E Manzillo, S Nappa. Padova: P Cadrobbi, R Scaggiante Palermo: A Colomba, T Prestilco. Pavia: G Filice, L Minoli, FA Patruno Savino, R Maserati. Perugia: S Pauluzzi, A Tosti. Piacenza: F Alberici, M Sisti. Pisa: F Menichetti, A Smorfa. Potenza: C De Stefano, A La Gala. Ravenna: S Ranieri, G Ballardini. Reggio Emilia: L Bonazzi, MA Ursitti. Rimini: R Ciammarughi, M Arlotti. Roma: L Ortona (Scientific Committee), F Dianzani (Scientific Committee), A Antinori, C Arici, S D'Elia, G Ippolito, P Narciso, N Petrosillo, G Rezza, V Vullo, A De Luca, A Del Forno, MR Capobianchi, M Zaccarelli, P De Longis, M Ciardi, E Girardi, G D'Offizi, F Palmieri, P Pezzotti, M Lichter. Sassari: A Aceti, M Mannazzu. Torino: P Caramello, A Sinicco, ML Soranzo, D Giacobbi, M Sciandra, B Salassa. Varese: D Torre. Verbania: A Poggio, G Bottari. Venezia: E Raise, S Pasquinucci. Vicenza: F De Lalla, G Tositti. Taranto: F Resta, A Chimienti. UK London: A Cozzi Lepri. Cited Here...

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Journal of Infectious Diseases, 185(8): 1062-1069.

Expert Opinion on Emerging Drugs
Clinical progress of HIV-1 integrase inhibitors
Al-Mawsawi, LQ; Al-Safi, RI; Neamati, N
Expert Opinion on Emerging Drugs, 13(2): 213-225.
Journal of Virology
Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif
Altfeld, MA; Livingston, B; Reshamwala, N; Nguyen, PT; Addo, MM; Shea, A; Newman, M; Fikes, J; Sidney, J; Wentworth, P; Chesnut, R; Eldridge, RL; Rosenberg, ES; Robbins, GK; Brander, C; Sax, PE; Boswell, S; Flynn, T; Buchbinder, S; Goulder, PJR; Walker, BD; Sette, A; Kalams, SA
Journal of Virology, 75(3): 1301-1311.

Response to: Harrison TS, Macallan DC, Rayner CFJ, Wansborough-Jones M. Treatment of tuberculosis in HIV-infected individuals AIDS 2002
Edwards, S; Pozniak, AL; Miller, R
AIDS, 16(): 1571-1572.

Archives of Internal Medicine
Incidence of adipose tissue alterations in first-line antiretroviral therapy - The LipoICoNa study
Galli, M; Cozzi-Lepri, A; Ridolfo, AL; Gervasoni, C; Ravasio, L; Corsico, L; Gianelli, E; Vaccarezza, M; Vullo, V; Cargnel, A; Minoli, L; Coronado, O; Giacometti, A; Antinori, A; Antonucci, G; Monforte, AD; Moroni, M
Archives of Internal Medicine, 162(): 2621-2628.

Clinical Infectious Diseases
Incidence of and risk factors for adverse drug reactions in a prospective cohort of HIV-infected adults initiating protease inhibitor-containing therapy
Duval, X; Journot, V; Leport, C; Chene, G; Dupon, M; Cuzin, L; May, T; Morlat, P; Waldner, A; Salamon, R; Raffi, F
Clinical Infectious Diseases, 39(2): 248-255.

Quality of Life Research
ISSQoL: A new questionnaire for evaluating the quality of life of people living with HIV in the HAART era
Bucciardini, R; Murri, R; Guarinieri, M; Starace, F; Martini, M; Vatrella, A; Cafaro, L; Fantoni, M; Grisetti, R; Monforte, AD; Fragola, V; Arcieri, R; Del Borgo, C; Tramarin, A; Massella, M; Lorenzetti, D; Vella, S
Quality of Life Research, 15(3): 377-390.
Jaids-Journal of Acquired Immune Deficiency Syndromes
Behavioral correlates of adherence to antirettoviral therapy
Aloisi, MS; Arici, C; Balzano, R; Noto, P; Piscopo, R; Filice, G; Menichetti, F; D'Arminio Monforte, A; Ippolito, G; Girardi, E
Jaids-Journal of Acquired Immune Deficiency Syndromes, 31(): S145-S148.

Expanding access to HIV antiretroviral therapy among marginalized populations in the developed world
Wood, E; Montaner, JSG; Bangsberg, DR; Tyndall, MW; Strathdee, SA; O'Shaughnessy, MV; Hogg, RS
AIDS, 17(): 2419-2427.

Antiviral Therapy
Response to HAART and GB virus type C coinfection in a cohort of antiretroviral-naive HIV-infected individuals
Antonucci, G; Girardi, E; Cozzi-Lepri, A; Capobianchi, MR; Morsica, G; Pizzaferri, P; Ladisa, N; Sighinolfi, L; Chiodera, A; Solmone, M; Lalle, E; Ippolito, G; Monforte, AD
Antiviral Therapy, 10(1): 109-117.

Journal of Infectious Diseases
A comparison between abacavir and efavirenz as the third drug used in combination with a background therapy regimen of 2 nucleoside reverse-transcriptase inhibitors in patients with initially suppressed viral loads
Cozzi-Lepri, A; De Luca, A; Phillips, AN; Bongiovanni, M; Di Giambenedetto, S; Mena, M; Moioli, MC; Arlotti, M; Sighinolfi, L; Narciso, P; Lichtner, M; Cauda, R; Monforte, AD
Journal of Infectious Diseases, 194(1): 20-28.

New England Journal of Medicine
Class of antiretroviral drugs and the risk of myocardial infarction
Friis-Moller, N; Reiss, P; Sabin, CA; Weber, R; Monforte, AD; El-Sadr, W; De Wit, S; Kirk, O; Fontas, E; Law, MG; Phillips, A; Lundgren, JD
New England Journal of Medicine, 356(): 1723-1735.

American Journal of Health-System Pharmacy
Effects of pharmacists' interventions on patient outcomes in an HIV primary care clinic
March, K; Mak, M; Louie, SG
American Journal of Health-System Pharmacy, 64(): 2574-2578.
HIV Clinical Trials
An immunological comparison of third companion in advanced drug-naive HIV-Infected patients
Rizzardini, G; Trabattoni, D; Capetti, A; Castelletti, E; Migliorino, M; Panebianco, R; Pacei, M; Quirino, T; Clerici, M
HIV Clinical Trials, 7(5): 221-228.
Pathologie Biologie
Recent and future therapeutic advances in the management of HIV infection
Saliba, G; Yeni, P
Pathologie Biologie, 54(): 545-550.
Statistics in Medicine
Evaluating competing adverse and beneficial outcomes using a mixture model
Lau, B; Cole, SR; Moore, RD; Gange, SJ
Statistics in Medicine, 27(): 4313-4327.
Enfermedades Infecciosas Y Microbiologia Clinica
First antiretroviral therapy regimen in HIV-infected patients. Durability and factors associated with therapy changes
de la Torre, J; Santos, J; Perea-Milla, E; Perez, I; Moreno, F; Palacios, R; Santamaria, S; del Arco, A; Nuno, E; Godoy, M; Prada, JL; Olalla, J; Aguilar, J; Martos, F
Enfermedades Infecciosas Y Microbiologia Clinica, 26(7): 416-422.

Journal of Acquired Immune Deficiency Syndromes
Outcome of a second-line protease inhibitor-containing regimen in patients failing or intolerant of a first highly active antiretroviral therapy
Bini, T; Testa, L; Chiesa, E; Adorni, F; Abeli, C; Castelnuovo, B; Melzi, S; Sollima, S; Bongiovanni, M; Monforte, AD
Journal of Acquired Immune Deficiency Syndromes, 24(2): 115-122.

European Journal of Epidemiology
Antiretroviral therapy in HIV-infected individuals in clinical practice: Are the criteria for initiating and choosing the type of drug regimen based only on immunologic and virologic values?
Pezzotti, P; Monforte, AD; Bugarini, R; Rezza, G; Arici, C; Angarano, G; Borderi, M; Alberici, F; Armignacco, O; Menichetti, F; Prestileo, T; Sighinolfi, L; Sinicco, A; Resta, F; Vigevani, M; Ippolito, G
European Journal of Epidemiology, 16(): 919-926.

Brazilian Journal of Infectious Diseases
Self-reported adverse reactions among patients initiating antiretroviral therapy in brazil
de Padua, CA; Cesar, CC; Bonolo, PF; Acurcio, FA; Guimaraes, MDC
Brazilian Journal of Infectious Diseases, 11(1): 20-26.

Sexual Health
Triple-class HIV antiretroviral therapy failure in an Australian primary care setting
Bloch, M; Farris, M; Tilden, D; Gowers, A; Cunningham, N
Sexual Health, 7(1): 17-24.
Female sex and the use of anti-allergic agents increase the risk of developing cutaneous rash associated with nevirapine therapy
Antinori, A; Baldini, F; Girardi, E; Cingolani, A; Zaccarelli, M; Di Giambenedetto, S; Barracchini, A; De Longis, P; Murri, R; Tozzi, V; Ammassari, A; Rizzo, MG; Ippolito, G; De Luca, A
AIDS, 15(): 1579-1581.

British Medical Journal
Highly active antiretroviral therapy
Murri, R
British Medical Journal, 330(): 681-682.

HIV Medicine
In the era of highly active antiretroviral therapy, why are HIV-infected patients still admitted to hospital for an inaugural opportunistic infection?
Perbost, I; Malafronte, B; Pradier, C; Santo, LDI; Dunais, B; Counillon, E; Vinti, H; Enel, P; Fuzibet, JG; Cassuto, JP; Dellamonica, P
HIV Medicine, 6(4): 232-239.

Brazilian Journal of Medical and Biological Research
High incidence of adverse reactions to initial antiretroviral therapy in Brazil
de Padua, CAM; Cesar, CC; Bonolo, PF; Acurcio, FA; Guimaraes, MDC
Brazilian Journal of Medical and Biological Research, 39(4): 495-505.

Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes
Ledergerber, B; Lundgren, JD; Walker, AS; Sabin, C; Justice, A; Reiss, P; Mussini, C; Wit, F; Monforte, AD; Weber, R; Fusco, G; Staszewski, S; Law, M; Hogg, R; Lampe, F; Gill, MJ; Castelli, F; Phillips, AN; Castelli, F; Fusco, GP; Gill, MJ; Hogg, R; Lampe, F; Law, M; Ledergerber, B; Lundgren, JD; Monforte, AD; Mussini, C; Phillips, AN; Reiss, P; Staszewski, S; Walker, AS; Rooney, P; Taylor, S; Couldwell, D; Austin, D; Block, M; Clemons, J; Finlayson, R; Law, M; Petoumenos, K; Quan, D; Smith, D; O'Connor, C; Gorton, C; Allen, D; Mulhall, B; Mutimer, K; Smith, D; Keeffe, N; Cooper, D; Carr, A; Miller, J; Pell, C; Ellis, D; Baker, D; Kidd, J; McFarlane, R; Liang, MT; Brown, K; Huffam, S; Savage, J; Morgan, S; Knibbs, P; Sowden, D; Walker, A; Orth, D; Lister, G; Chuah, J; Fankhauser, W; Dickson, B; Bradford, D; Wilson, C; Ree, H; Magon, H; Anderson, J; Moore, R; Russell, D; McGovern, G; McNair, R; Bal, J; Fairley, K; Roth, N; Eu, B; Strecker, S; Russell, D; Wood, H; Mijch, A; Hoy, J; Pierce, A; McCormack, C; Watson, K; Medland, N; Daye, J; Mallal, S; French, M; Skett, J; Maxwel, D; Cain, A; Montroni, M; Scalise, G; Costantini, A; Giacometti, A; Tirelli, U; Nasti, G; Pastore, G; Ladisa, N; Perulli, ML; Suter, F; Arici, C; Chiodo, F; Gritti, FM; Colangeli, V; Fiorini, C; Guerra, L; Carosi, G; Cadeo, GP; Castelli, F; Minardi, C; Vangi, D; Rizzardini, G; Migliorino, G; Manconi, PE; Piano, P; Ferraro, T; Scerbo, A; Pizzigallo, E; Ricci, F; Santoro, D; Pusterla, L; Carnevale, G; Galloni, D; Vigano, P; Mena, M; Ghinelli, F; Sighinolfi, L; Leoncini, F; Mazzotta, F; Pozzi, M; Lo Caputo, S; Angarano, G; Grisorio, B; Ferrara, S; Grima, P; Tundo, P; Pagano, G; Piersantelli, N; Alessandrini, A; Piscopo, R; Toti, M; Chigiotti, S; Soscia, F; Taccooni, L; Orani, A; Perini, P; Scasso, A; Vincenti, A; Scalzini, A; Fibbia, G; Moroni, M; Lazzarin, A; Cargnel, A; Vigevani, GM; Caggese, L; Monforte, AD; Tordato, F; Novati, R; Galli, A; Merli, S; Pastecchia, C; Moioli, C; Esposito, R; Mussini, C; Abrescia, N; Chirianni, A; Izzo, C; Piazza, M; De Marco, M; Montesarchio, V; Manzillo, E; Nappa, S; Colomba, A; Abbadessa, V; Prestileo, T; Mancuso, S; Ferrari, C; Pzzaferri, P; Filice, G; Minoli, L; Bruno, R; Maserati, R; Pauluzzi, S; Baldelli, F; Petrelli, E; Cioppi, A; Alberici, F; Ruggieri, A; Menichetti, F; Martinelli, C; De Stefano, C; La Gala, A; Zauli, T; Ballardini, G; Magnani, G; Ursitti, MA; Arlotti, M; Ortolani, P; Ortona, L; Dianzani, F; Ippolito, G; Antinori, A; Antonucci, G; D'Elia, S; Narciso, P; Petrosillo, N; Vullo, V; De Luca, A; Del Forno, L; Zaccarelli, M; De Longis, P; Ciardi, M; D'Offizi, G; Noto, P; Lichtner, M; Capobianchi, MR; Girardi, E; Pezzotti, P; Rezza, G; Mura, MS; Mannazzu, M; Caramello, P; Sinicco, A; Soranzo, ML; Gennero, L; Sciandra, M; Salassa, B; Grossi, PA; Basilico, C; Poggio, A; Bottari, G; Raise, E; Pasquinucci, S; De Lalla, F; Tositti, G; Resta, F; Chimienti, A; Lepri, AC; Bachmann, S; Battegay, M; Bernasconi, E; Bucher, H; Burgisser, P; Cattacin, S; Egger, M; Erb, P; Fierz, W; Fischer, M; Flepp, M; Fontana, A; Francioli, P; Furrer, HJ; Gorgievski, M; Gunthard, H; Hirschel, B; Kaiser, L; Kind, C; Klimkait, T; Ledergerber, B; Lauper, U; Opravil, M; Paccaud, F; Pantaleo, G; Perrin, L; Piffaretti, JC; Rickenbach, M; Rudin, C; Schupbach, J; Speck, R; Tarr, P; Telenti, A; Trkola, A; Vernazza, P; Weber, R; Yerly, S; de Wolf, F; van Sighem, AI; van Valkengoed, I; Gras, L; Bronsveld, W; Prins, JM; Bos, JC; Schattenkerk, JKME; Godfried, MH; Lange, JMA; Lowe, SH; van der Meer, JTM; Nellen, FJB; Pogany, K; van der Poll, T; Reiss, P; Ruys, TA; Sankatsing, S; van der Valk, M; van Vonderen, MGA; Wit, FWMN; van Eeden, A; ten Veen, JH; van Dam, PS; Hillebrand-Haverkort, ME; Brinkman, K; Frissen, PHJ; Weigel, HM; Mulder, JW; van Gorp, ECM; Meenhorst, PL; Mairuhu, ATA; Veenstra, J; Danner, SA; Van Agtmael, MA; Claessen, FAP; Geerlings, SE; Perenboom, RM; Richter, C; van der Berg, J; van Leusen, R; Vriesendorp, R; Jeurissen, FJF; Kauffmann, RH; Koger, ELW; Bravenboer, B; ten Napel, CHH; Mudrikova, T; Sprenger, HG; Miesen, WMAJ; ten Kate, RW; van Houte, DPF; Leemhuis, MP; Pole, M; Kroon, FP; Schippers, EF; Schreij, G; van de Geest, S; Verbon, A; Koopmans, PP; Telgt, M; van der Ven, AJAM; van der Ende, ME; Gyssens, IC; de Marie, S; Nouwen, JL; Juttmann, JR; Schneider, MME; Bonten, MJM; Borleffs, JCC; Hoepelman, IM; Jaspers, CAJJ; Schouten, I; Schurink, CAM; Blok, WL; Groenveld, PHP; Jurriaans, S; Back, NKT; Cuijpers, T; Rietra, PJGM; Roozendaal, KJ; Pauw, W; van Zanten, AP; Smits, PHM; von Blomberg, BME; Savelkoul, P; Zaaijer, H; Swanink, C; Franck, PFH; Lampe, AS; Jansen, CL; Hendriks, R; Schirm, J; Benne, D; Veenendaal, D; Storm, H; van Zeijl, JH; Kroes, ACM; Claas, HCJ; Bruggeman, CAMVA; Goossens, VJ; Galama, JMD; Poort, YAGM; Niesters, MG; Osterhaus, ADME; Schutten, M; Buiting, AGM; Swaans, CAM; Boucher, CAB; Schuurman, R; Boel, E; Jansz, AF; Veldkamp, A; Beijnen, JH; Crommentuyn, KML; Huitema, ADR; Kappelhoff, B; de Maat, MMR; Burger, DM; Hugen, PWH; Dabis, F; Thiebaut, R; Chene, G; Lawson-Ayayi, S; Meyer, L; Boufassa, F; Hamouda, O; Pezzotti, P; Rezza, G; Touloumi, G; Hatzakis, A; Karafoulidou, A; Katsarou, O; Brettle, R; Del Amo, J; del Romero, J; van Asten, L; van Benthem, B; Prins, M; Coutinho, R; Kirk, O; Pedersen, C; Aguado, IH; Perez-Hoyos, S; Eskild, A; Bruun, JN; Sannes, M; Sabin, C; Lee, C; Johnson, AM; Phillips, AN; Babiker, A; Darbyshire, J; Gill, N; Porter, K; Francioli, P; Vanhems, P; Egger, M; Rickenbach, M; Cooper, D; Kaldor, J; Ashton, L; Cooper, D; Kaldor, J; Ashton, L; Cooper, D; Vizzard, J; Muga, R; Vanhems, P; Gill, J; Cayla, J; de Olalla, PG; Day, NE; De Angelis, D; Porter, K; Babiker, A; Walker, S; Darbyshire, J; Tyrer, F; Beral, V; Coutinho, R; Darbyshire, J; Del Amo, J; Gill, N; Lee, C; Meyer, L; Rezza, G; Raffanti, S; Becker, S; Scarsella, A; Braun, J; Justice, A; Fusco, G; Most, B; Balu, R; Gilbert, L; Fleenor, R; Ising, T; Dieterich, D; Fusco, J; Losso, M; Duran, A; Vetter, N; Clumeck, N; De Wit, S; Kabeya, K; Poll, B; Colebunders, R; Machala, L; Rozsypal, H; Nielsen, J; Lundgren, J; Kirk, O; Olsen, CH; Gerstoft, J; Katzenstein, T; Hansen, ABE; Skinhoj, P; Pedersen, C; Zilmer, K; Rauka, M; Katlama, C; De Sa, M; Viard, JP; Saint-Marc, T; Vanhems, P; Pradier, C; Dietrich, M; Manegold, C; van Lunzen, J; Stellbrink, HJ; Miller, V; Staszewski, S; Goebel, FD; Salzberger, B; Rockstroh, J; Kosmidis, J; Gargalianos, P; Sambatakou, H; Perdios, J; Panos, G; Filandras, A; Banhegyi, D; Mulcahy, F; Yust, I; Burke, M; Pollack, S; Hassoun, J; Sthoeger, Z; Maayan, S; Vella, S; Chiesi, A; Arici, C; Pristera, R; Mazzotta, F; Gabbuti, A; Esposito, R; Bedini, A; Chirianni, A; Montesarchio, E; Vullo, V; Santopadre, P; Narciso, P; Antinori, A; Franci, P; Zaccarelli, M; Lazzarin, A; Castagna, A; Monforte, AD; Viksna, L; Rozentale, B; Chaplinskas, S; Hemmer, R; Staub, T; Reiss, P; Bruun, J; Maeland, A; Ormaasen, V; Knysz, B; Gasiorowski, J; Horban, A; Prokopowicz, D; Wiercinska-Drapalo, A; Boron-Kaczmarska, A; Pynka, M; Beniowski, M; Trocha, H; Smiatacz, T; Antunes, F; Mansinho, K; Maltez, F; Duiculescu, D; Streinu-Cercel, A; Mokras, M; Stanekova, D; Gonzalez-Lahoz, J; Diaz, B; Garcia-Benayas, T; Martin-Carbonero, L; Soriano, V; Clotet, B; Jou, A; Conejero, J; Tural, C; Gatell, JM; Miro, JM; Zamora, L; Blaxhult, A; Karlsson, A; Pehrson, P; Ledergerber, B; Weber, R; Francioli, P; Hirschel, B; Schiffer, V; Furrer, H; Chentsova, N; Barton, S; Johnson, AM; Mercey, D; Phillips, A; Youle, M; Johnson, MA; Mocroft, A; Murphy, M; Weber, J; Scullard, G; Fisher, M; Brettle, R; Loveday, C; Clotet, B; Ruiz, L; Staszewski, S; Helm, EB; Carlebach, A; Mosch, M; Muller, A; Haberl, A; Korn, S; Stephan, C; Bickel, M; Gute, P; Locher, L; Lutz, T; Klauke, S; Doerr, HW; Sturmer, M; Sabin, C; Dauer, B; Jennings, B; Alexander, C; Braitstein, P; Chan, K; Cote, H; Gataric, N; Harrigan, PR; Harris, M; Bonner, S; Hogg, R; Montaner, J; O'Shaughnessy, M; Wood, E; Yip, B; Lampe, F; Chaloner, C; Gumley, H; Ransom, D; Sabin, CA; Mocroft, A; Lipman, M; Phillips, AN; Youle, M; Johnson, M; Gill, J; Read, R; Carosi, G; Castelli, F; Paraninfo, G; Casari, S; Pan, A; Patroni, A; Torti, C; Quiros-Roldan, E; Tomasoni, L; Moretti, F; Nasta, P; Uccelli, MC; Cadeo, GP; Bertelli, D; Orani, A; Perini, P; Nigro, M; Rizzardini, G; Migliorino, M; Abeli, C; Mazzotta, F; Suter, F; Maggiolo, F; Arici, C; Ghinelli, F; Sighinolfi, L; Minoli, L; Maserati, R; Novati, S; Tinelli, C; Pastore, G; Ladisa, N; Carnevale, G; Poggio, A; Riccio, G; Mussini, C; Borghi, V; Bedini, A; Esposito, R
Lancet, 364(): 51-62.

Clinical Infectious Diseases
Role of hepatitis C virus (HCV) viremia and HCV genotype in the immune recovery from highly active antiretroviral therapy in a cohort of antiretroviral-Naive HIV-Infected individuals
Antonucci, G; Girardi, E; Cozzi-Lepri, A; Capobianchi, MR; De Luca, A; Puoti, M; Petrelli, E; Carnevale, G; Rizzardini, G; Grossi, PA; Vigano, P; Moioli, MC; Carletti, F; Solmone, M; Ippolito, G; Monforte, AD
Clinical Infectious Diseases, 40(): E101-E109.

What a cardiologist needs to know about patients with human immunodeficiency virus infection
Hsue, PY; Waters, DD
Circulation, 112(): 3947-3957.
HIV Medicine
Determinants of discontinuation of initial highly active antiretroviral therapy regimens in a USHIV-infected patient cohort
Yuan, Y; L'Italien, G; Mukherjee, J; Iloeje, UH
HIV Medicine, 7(3): 156-162.

Antiviral Research
Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): Targeting Vpr and its cellular partner, the glucocorticoid receptor (GR)
Schafer, EA; Venkatachari, NJ; Ayyavoo, V
Antiviral Research, 72(3): 224-232.
Expert Opinion on Pharmacotherapy
Abacavir/lamividune combination in the treatment of HIV-1 infection: a review
Waters, L; Moyle, G
Expert Opinion on Pharmacotherapy, 7(): 2571-2580.
New England Journal of Medicine
Discontinuation of secondary prophylaxis against Pneumocystis carinii pneumonia in patients with HIV infection who have a response to antiretroviral therapy
Ledergerber, B; Mocroft, A; Reiss, P; Furrer, H; Kirk, O; Bickel, M; Uberti-Foppa, C; Pradier, C; Monforte, AD; Schneider, MME; Lundgren, JD
New England Journal of Medicine, 344(3): 168-174.

Clinical Microbiology and Infection
Overall trends in CD4 counts and plasma viremia in an urban clinic since the introduction of highly active antiretroviral therapies
Martin, JC; Soriano, V; Jimenez-Nacher, I; Martinez, P; Gonzalez-Lahoz, J
Clinical Microbiology and Infection, 7(): 678-681.

New England Journal of Medicine
Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapy
Sanders, GD; Bayoumi, AM; Sundaram, V; Bilir, SP; Neukermans, CP; Rydzak, CE; Douglass, LR; Lazzeroni, LC; Holodniy, M; Owens, DK
New England Journal of Medicine, 352(6): 570-585.

Recent acquired STD and the use of HAART in the italian cohort of naive for antiretrovirals (I.Co.N.A): Analysis of the incidence of newly acquired hepatitis B infection and syphilis
Cicconi, P; Cozzi-Lepri, A; Orlando, G; Matteelli, A; Girardi, E; Esposti, AD; Moioli, C; Rizzardini, G; Chiodera, A; Ballardini, G; Tincati, C; Monforte, AD
Infection, 36(1): 46-53.
HIV Medicine
The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy
Sabin, CA; Smith, CJ; Delpech, V; Anderson, J; Bansi, L; Gilson, R; Schwenk, A; Leen, C; Gazzard, B; Porter, K; Mackie, N; Fisher, M; Orkin, C; Johnson, M; Easterbrook, P; Hill, T; Phillips, AN
HIV Medicine, 10(1): 35-43.
Journal of Acquired Immune Deficiency Syndromes
Low frequency of severe hepatotoxicity and association with HCV coinfection in HIV-positive patients treated with HAART
Monforte, AD; Bugarini, R; Pezzotti, P; De Luca, A; Antinori, A; Mussini, C; Vigevani, GM; Tirelli, U; Bruno, R; Gritti, F; Piazza, M; Chigiotti, S; Chirianni, A; De Stefano, C; Pizzigallo, E; Perrella, O; Moroni, M
Journal of Acquired Immune Deficiency Syndromes, 28(2): 114-123.

Expert Opinion on Pharmacotherapy
Enfuvirtide: the first HIV fusion inhibitor
Lazzarin, A
Expert Opinion on Pharmacotherapy, 6(3): 453-464.

Antiviral Therapy
Variability in the interpretation of transmitted genotypic HIV-1 drug resistance and prediction of virological outcomes of the initial HAART by distinct systems
De Luca, A; Cozzi-Lepri, A; Perno, CF; Balotta, C; Di Giambenedetto, S; Poggio, A; Pagano, G; Tositti, G; Piscopo, R; Del Forno, A; Chiodo, F; Magnanio, G; Monforte, AD
Antiviral Therapy, 9(5): 743-752.

Antiviral Therapy
Are specific antiretrovirals associated with an increased risk of discontinuation due to toxicities or patient/physician choice in patients with hepatitis C virus coinfection?
Mocroft, A; Rockstroh, J; Soriano, V; Ledergerber, B; Kirk, O; Vinogradova, E; Reiss, P; Katlama, C; Phillips, AN; Lundgren, JD
Antiviral Therapy, 10(7): 779-790.

Letters in Drug Design & Discovery
Antiretroviral therapy: Is it the right time for new strategies?
Abrescia, N; D'Abbraccio, M; Busto, A; Maddaloni, A; Figoni, M; De Marco, M
Letters in Drug Design & Discovery, 2(6): 470-474.

High frequency of highly active antiretroviral therapy modifications in patients with acute or early human immunodeficiency virus infection
Sabundayo, BP; McArthur, JH; Langan, SJ; Gallant, JE; Margolick, JB
Pharmacotherapy, 26(5): 674-681.

Enfermedades Infecciosas Y Microbiologia Clinica
Cost of nucleoside analogue reverse transcriptase inhibitor-related toxicity in HIV-1-infected patients
Llibre-Codina, JM; Casado-Gomez, MA; Sanchez-de La Rosa, R; Perez-Elias, MJ; Santos-Gonzalez, J; Miralles-Alvarez, C; Martinez-Chamorro, E; Domingo-Pedrol, P; Alvarez-Garcia, ML; Moreno-Guillen, S
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Journal of the National Medical Association
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Plos Computational Biology
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International Journal of Tuberculosis and Lung Disease
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AIDS Patient Care and Stds
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Archives of Internal Medicine
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Von Wyl, V; Yerly, S; Boni, J; Burgisser, P; Klimkait, T; Battegay, M; Furrer, H; Telenti, A; Hirschel, B; Vernazza, PL; Bernasconi, E; Rickenbach, M; Perrin, L; Ledergerber, B; Gunthard, HF
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Journal of Gastroenterology and Hepatology
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Clinical Infectious Diseases
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Prosperi, MCF; Cozzi-Lepri, A; Castagna, A; Mussini, C; Murri, R; Giacometti, A; Torti, C; Costantini, A; Narciso, P; Ghinelli, F; Antinori, A; Monforte, AD
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Biomedicine & Pharmacotherapy
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Revista De Investigacion Clinica
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Journal of Medical Virology
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Jaids-Journal of Acquired Immune Deficiency Syndromes
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Strategies of HIV management - when to switch
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Special considerations in the initiation and management of antiretroviral therapy in individuals coinfected with HIV and hepatitis C
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International Journal of Antimicrobial Agents
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Biological Research for Nursing
Genome-Wide Screen Identifies Drug-Induced Regulation of the Gene Giant Axonal Neuropathy (Gan) in a Mouse Model of Antiretroviral-Induced Painful Peripheral Neuropathy
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Journal of Acquired Immune Deficiency Syndromes
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Jama-Journal of the American Medical Association
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Journal of Plastic Reconstructive and Aesthetic Surgery
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Medical Science Monitor
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Bmc Infectious Diseases
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Antiretroviral treatment changes in adults from Côte d'Ivoire: the roles of tuberculosis and pregnancy
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AIDS, 20(3): 323-331.
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AIDS, 16(7): 1084-1086.

When to start highly active antiretroviral therapy in chronically HIV-infected patients: evidence from the ICONA study
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AIDS, 22(9): 1039-1046.
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AIDS, 22(15): 1951-1960.
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highly active antiretroviral therapy (HAART); first antiretroviral regimen; discontinuation; toxicity; failure

© 2000 Lippincott Williams & Wilkins, Inc.


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