Improving estimates of children living with HIV from the Spectrum AIDS Impact Model

Mahy, Mary; Penazzato, Martina; Ciaranello, Andrea; Mofenson, Lynne; Yianoutsos, Constantin T.; Davies, Mary-Ann; Stover, John

AIDS:
doi: 10.1097/QAD.0000000000001306
Supplement Article
Abstract

Objective: Estimated numbers of children living with HIV determine programmatic and treatment needs. We explain the changes made to the UNAIDS estimates between 2015 and 2016, and describe the challenges around these estimates.

Methods: Estimates of children newly infected, living with HIV, and dying of AIDS are developed by country teams using Spectrum software. Spectrum files are available for 160 countries, which represent 98% of the global population. In 2016, the methods were updated to reflect the latest evidence on mother-to-child HIV transmission and improved assumptions on the age children initiate antiretroviral therapy. We report updated results using the 2016 model and validate these estimates against mother-to-child transmission rates and HIV prevalence from population-based surveys for the survey year.

Results: The revised 2016 model estimates 27% fewer children living with HIV in 2014 than the 2015 model, primarily due to changes in the probability of mother-to-child transmission among women with incident HIV during pregnancy. The revised estimates were consistent with population-based surveys of HIV transmission and HIV prevalence among children aged 5–9 years, but were lower than surveys among children aged 10–14 years.

Conclusions: The revised 2016 model is an improvement on previous models. Paediatric HIV models will continue to evolve as further improvements are made to the assumptions. Commodities forecasting and programme planning rely on these estimates, and increasing accuracy will be critical to enable effective scale-up and optimal use of resources. Efforts are needed to improve empirical measures of HIV prevalence, incidence, and mortality among children.

Author Information

aJoint UN Programme on HIV/AIDS

bHIV Department, World Health Organization, Geneva, Switzerland

cMassachusetts General Hospital, Boston, Massachusetts

dElizabeth Glaser Pediatric AIDS Foundation, Washington, District of Columbia

eIndiana University, Indianapolis, Indiana, USA

fUniversity of Cape Town, Cape Town, South Africa

gAvenir Health, Glastonbury, Connecticut, USA.

Correspondence to Mary Mahy, 20 Avenue Appia, Geneva 27, Switzerland. E-mail: mahym@unaids.org

Received 24 August, 2016

Revised 5 October, 2016

Accepted 10 October, 2016

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