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AIDS:
doi: 10.1097/QAD.0000000000000312
Research Letters

Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes

Vinuesa, Davida; Parra-Ruiz, Jorgea; Chueca, Nataliab; Alvarez, Martab; Muñoz-Medina, Leopoldoa; Garcia, Federicob; Hernandez-Quero, Josea

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Abstract

There are concerns about residual viremia in sanctuary sites among patients on protease inhibitor monotherapy, so we aimed to study viro-immunological parameters in tonsil's lymphoid tissue of patients on highly active antiretroviral therapy (HAART) and on protease inhibitor monotherapy. Despite fully suppressed serum HIV viral load, we found viral replication in both groups; in addition, more patients had detectable proviral DNA among those on HAART, compared to those on protease inhibitor monotherapy (P = 0.08), supporting the absence of a deleterious effect of protease inhibitor monotherapy.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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