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AIDS:
doi: 10.1097/QAD.0000000000000354
Basic Science

Polymorphism in interleukin-7 receptor α gene is associated with faster CD4+ T-cell recovery after initiation of combination antiretroviral therapy

Hartling, Hans J.a,b,c; Thørner, Lise W.c; Erikstrup, Christiand; Harritshøj, Lene H.c; Kronborg, Gittee; Pedersen, Courtf; Larsen, Carsten S.g; Helleberg, Mariea; Gerstoft, Jana; Obel, Nielsa; Ullum, Henrikc; Nielsen, Susanne D.a,b

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Abstract

Objectives:

To investigate single-nucleotide polymorphisms (SNPs) in the gene encoding interleukin-7 receptor α (IL7RA) as predictors for CD4+ T-cell change after initiation of combination antiretroviral therapy (cART) in HIV-infected whites.

Design:

SNPs in IL7RA were determined in the Danish HIV Cohort Study.

Methods:

CD4+ T-cell changes were estimated 6 months, 1, 2, and 5 years after initiation of cART in 1683 HIV-infected virally suppressed individuals. Five SNPs in IL7RA were examined as predictors for CD4+ T-cell change in the first (0–6 months after initiation of cART) and second phase (>6 months after initiation of cART) of immune recovery. Univariable and multivariable analyses including age, sex, calendar period, CD4+ nadir, and baseline CD4+ T-cell count and viral load as covariates were performed.

Results:

Individuals carrying two T-alleles in rs6897932 had faster CD4+ T-cell recovery compared with individuals carrying a C-allele in the first phase of immune recovery [mean CD4+ T-cell change, cells/μL (95% confidence interval), in TT: 177 (151–203), CT: 131 (119–143), CC: 141 (132–151), P = 0.018]. No isolated effect of rs6897932 on CD4+ T-cell change was found in the second phase of immune recovery; however, the initial difference in CD4+ T-cell recovery remained during 5 years. The effect was most pronounced in individuals above 40 years of age.

Conclusion:

T-allele homozygosity in rs6897932 is a predictor for faster CD4+ T-cell recovery after initiation of cART in HIV-infected whites, however, only in the first phase of immune recovery.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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