Skip Navigation LinksHome > July 31, 2014 - Volume 28 - Issue 12 > High prevalence of subtype F in newly diagnosed HIV-1 person...
doi: 10.1097/QAD.0000000000000326
Research Letters

High prevalence of subtype F in newly diagnosed HIV-1 persons in northwest Spain and evidence for impaired treatment response

Pernas, Bertaa; Grandal, Martaa; Mena, Alvaroa; Castro-Iglesias, Angelesa; Cañizares, Angelinab; Wyles, David L.d; López-Calvo, Soledada; Pértega, Soniac; Rodríguez-Osorio, Iriaa; Pedreira, Jose Domingoa; Poveda, Evaa

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HIV-1 non-B subtype variants were found in 37.8% of 296 newly diagnosed persons in northwest Spain over the past 5 years. Subtype F was the most prevalent non-B subtype (29.6%) and displayed preferential transmission among MSM. Virologic response rates to antiretroviral therapy were lower among F subtypes compared to B subtypes at weeks 24 (31% vs. 78.3%), 48 (51.7% vs. 85.2%), and 96 (61.1% vs. 94.3%) of therapy. Subtype F was independently associated with virological response at 24 weeks.

© 2014 Lippincott Williams & Wilkins, Inc.


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