High prevalence of subtype F in newly diagnosed HIV-1 persons in northwest Spain and evidence for impaired treatment response

Pernas, Bertaa; Grandal, Martaa; Mena, Alvaroa; Castro-Iglesias, Angelesa; Cañizares, Angelinab; Wyles, David L.d; López-Calvo, Soledada; Pértega, Soniac; Rodríguez-Osorio, Iriaa; Pedreira, Jose Domingoa; Poveda, Evaa

doi: 10.1097/QAD.0000000000000326
Research Letters

HIV-1 non-B subtype variants were found in 37.8% of 296 newly diagnosed persons in northwest Spain over the past 5 years. Subtype F was the most prevalent non-B subtype (29.6%) and displayed preferential transmission among MSM. Virologic response rates to antiretroviral therapy were lower among F subtypes compared to B subtypes at weeks 24 (31% vs. 78.3%), 48 (51.7% vs. 85.2%), and 96 (61.1% vs. 94.3%) of therapy. Subtype F was independently associated with virological response at 24 weeks.

aGrupo de Virología Clínica

bServicio de Microbiología

cUnidad de Epidemiología Clínica y Bioestadística, INIBIC-Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain

dDivision of Infectious Diseases, University of California, San Diego, La Jolla, California, USA.

Correspondence to Dr Eva Poveda, Grupo de Virología Clínica, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), As Xubias s/n, A Coruña 15006, Spain. Tel: +34 981 17 63 99; fax: +34 981 17 63 98; e-mail: eva.poveda.lopez@sergas.es

Received 18 March, 2014

Revised 29 April, 2014

Accepted 30 April, 2014

© 2014 Lippincott Williams & Wilkins, Inc.