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AIDS:
doi: 10.1097/QAD.0000000000000319
Research Letters

T-cell activation positively correlates with cell-associated HIV-DNA level in viremic patients with primary or chronic HIV-1 infection

Weiss, Laurencea,b,c; Chevalier, Mathieu F.b,d,∗; Assoumou, Lamberte,f; Didier, Célineb; Girard, Pierre-Marieg; Piketty, Christophec; Costagliola, Dominiquee,f; Rouzioux, Christineh

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Abstract

We investigated the relationship between the size of blood HIV reservoirs and T-cell activation in patients with primary HIV infection (PHI) and chronic HIV infection (CHI) before and after antiretroviral therapy (ART) interruption. Levels of T-cell activation strongly positively correlated with HIV-DNA levels in viremic PHI and CHI patients. In ART-treated CHI patients, residual immune activation was not associated with HIV-DNA levels. Interestingly, early levels of HIV-DNA in PHI predicted the extent of residual T-cell proliferation under ART.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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