HLA-B*35 has consistently been associated with rapid HIV disease progression, particularly alleles of the Px group. As B*35 is the most prevalent HLA-B in Mexico, we investigated HIV disease outcome in relation to HLA expression in a large cohort (n = 976) of Mexicans. Contrary to the previous studies, no impact on viral load or CD4+ cell count was observed in association with the B*35 PY/Px groups. However, we observed differences in HIV disease outcome associated with specific HLA-B*35 alleles.
aDepartment of Paediatrics, University of Oxford, Oxford, UK
bCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.
*Claudia I. Juarez-Molina and Humberto Valenzuela-Ponce contributed equally to the writing of this article.
Correspondence to Gustavo Reyes-Teran, National Institute of Respiratory Diseases, Calzada de Tlalpan 4502, Col. Sección XVI, 14080 Mexico City, Mexico. E-mail: email@example.com
Received 15 April, 2014
Revised 25 April, 2014
Accepted 28 April, 2014