Skip Navigation LinksHome > July 17, 2014 - Volume 28 - Issue 11 > Impact of HLA-B∗35 subtype differences on HIV disease outcom...
AIDS:
doi: 10.1097/QAD.0000000000000322
Research Letters

Impact of HLA-B∗35 subtype differences on HIV disease outcome in Mexico

Juarez-Molina, Claudia I.a,∗; Valenzuela-Ponce, Humbertob,∗; Avila-Rios, Santiagob; Garrido-Rodriguez, Danielab; Garcia-Tellez, Thalíab; Soto-Nava, Maribelb; Garcia-Morales, Claudiab; Goulder, Philipa; Reyes-Teran, Gustavob

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Abstract

HLA-B35 has consistently been associated with rapid HIV disease progression, particularly alleles of the Px group. As B35 is the most prevalent HLA-B in Mexico, we investigated HIV disease outcome in relation to HLA expression in a large cohort (n = 976) of Mexicans. Contrary to the previous studies, no impact on viral load or CD4+ cell count was observed in association with the B35 PY/Px groups. However, we observed differences in HIV disease outcome associated with specific HLA-B35 alleles.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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