CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on lsong-term antiretroviral therapy and correlate with CD8+ T-cell immune activation

Greathead, Louisea; Metcalf, Rebeccaa; Gazzard, Brianb; Gotch, Francesa; Steel, Alanc; Kelleher, Petera,b

AIDS:
doi: 10.1097/QAD.0000000000000351
Research Letters
Abstract

Mucosal-associated invariant T (MAIT) cells are tissue-homing T cells recently implicated in HIV pathogenesis. We found that the proportion of MAIT cell in blood and colon of HIV+ patients are reduced in untreated infection. Antiretroviral therapy restored colonic but not blood MAIT cell percentages. We observed a negative correlation between colonic MAIT cells and T-cell activation in blood and suggest mucosal MAIT cell depletion may contribute to systemic immune activation in HIV infection.

Author Information

aImmunology Section, Division of Infectious Diseases, Imperial College Chelsea & Westminster Hospital

bHIV & Sexual Health Directorate

cDepartment of Gastroenterology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

Correspondence to Peter Kelleher, Immunology Section, Imperial College, Chelsea & Westminster Hospital, 369 Fulham Road, SW10 9NH London, UK. E-mail: p.kelleher@ic.ac.uk

Received 10 September, 2013

Revised 15 May, 2014

Accepted 15 May, 2014

© 2014 Lippincott Williams & Wilkins, Inc.