Skip Navigation LinksHome > July 17, 2014 - Volume 28 - Issue 11 > CD8+/CD161++ mucosal-associated invariant T-cell levels in t...
AIDS:
doi: 10.1097/QAD.0000000000000351
Research Letters

CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on lsong-term antiretroviral therapy and correlate with CD8+ T-cell immune activation

Greathead, Louisea; Metcalf, Rebeccaa; Gazzard, Brianb; Gotch, Francesa; Steel, Alanc; Kelleher, Petera,b

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Abstract

Mucosal-associated invariant T (MAIT) cells are tissue-homing T cells recently implicated in HIV pathogenesis. We found that the proportion of MAIT cell in blood and colon of HIV+ patients are reduced in untreated infection. Antiretroviral therapy restored colonic but not blood MAIT cell percentages. We observed a negative correlation between colonic MAIT cells and T-cell activation in blood and suggest mucosal MAIT cell depletion may contribute to systemic immune activation in HIV infection.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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