Mucosal-associated invariant T (MAIT) cells are tissue-homing T cells recently implicated in HIV pathogenesis. We found that the proportion of MAIT cell in blood and colon of HIV+ patients are reduced in untreated infection. Antiretroviral therapy restored colonic but not blood MAIT cell percentages. We observed a negative correlation between colonic MAIT cells and T-cell activation in blood and suggest mucosal MAIT cell depletion may contribute to systemic immune activation in HIV infection.
aImmunology Section, Division of Infectious Diseases, Imperial College Chelsea & Westminster Hospital
bHIV & Sexual Health Directorate
cDepartment of Gastroenterology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Correspondence to Peter Kelleher, Immunology Section, Imperial College, Chelsea & Westminster Hospital, 369 Fulham Road, SW10 9NH London, UK. E-mail: firstname.lastname@example.org
Received 10 September, 2013
Revised 15 May, 2014
Accepted 15 May, 2014