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AIDS:
doi: 10.1097/QAD.0000000000000364
Research Letters

Is impaired kidney function an independent predictor of the risk of myocardial infarction in HIV-infected individuals?

Lang, Sylviea,b; Mary-Krause, Muriellea,b; Partisani, Marialuisac; Gilquin, Jacquesd,e; Simon, Annef; Cotte, Laurentg,h; Boccara, Francki,j,k; Costagliola, Dominiquea,b

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Abstract

We examined whether impaired kidney function is an independent risk factor for myocardial infarction in HIV-infected individuals without pre-existing coronary artery disease. The odds ratio for impaired kidney function fell from 1.22 (95% confidence interval 0.90–1.66) to 0.99 (95% confidence interval 0.69–1.41) after adjustment for cardiovascular risk factors and HIV-related parameters, with hypertension, high-density lipoprotein cholesterol, smoking and the CD4+ T-cell nadir as most influential confounders. In this setting, no association was found between impaired kidney function and the risk of myocardial infarction.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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