Is impaired kidney function an independent predictor of the risk of myocardial infarction in HIV-infected individuals?

Lang, Sylviea,b; Mary-Krause, Muriellea,b; Partisani, Marialuisac; Gilquin, Jacquesd,e; Simon, Annef; Cotte, Laurentg,h; Boccara, Francki,j,k; Costagliola, Dominiquea,b; for the French Hospital Database on HIV-ANRS CO4

AIDS:
doi: 10.1097/QAD.0000000000000364
Research Letters
Abstract

We examined whether impaired kidney function is an independent risk factor for myocardial infarction in HIV-infected individuals without pre-existing coronary artery disease. The odds ratio for impaired kidney function fell from 1.22 (95% confidence interval 0.90–1.66) to 0.99 (95% confidence interval 0.69–1.41) after adjustment for cardiovascular risk factors and HIV-related parameters, with hypertension, high-density lipoprotein cholesterol, smoking and the CD4+ T-cell nadir as most influential confounders. In this setting, no association was found between impaired kidney function and the risk of myocardial infarction.

Author Information

aINSERM, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique

bSorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris

cHôpitaux Universitaires de Strasbourg, Le Trait D’Union, centre de soins de l’infection par le VIH, Strasbourg

dAPHP, Hôtel Dieu, Unité d’immuno-infectiologie

eCentre Médical de l’Institut Pasteur

fAPHP, Hôpital Pitié-Salpêtrière, service de médecine interne I, Paris

gHospices Civils de Lyon, Hôpital de la Croix Rousse, service des maladies infectieuses et tropicales

hINSERM, U 1052, Lyon

iAPHP, Hôpital Saint-Antoine, service de cardiologie

jINSERM, UMR_S 938

kSorbonne Universités, UPMC Univ Paris 06, UMR_S 938, Paris, France.

*The full list of FHDH-ANRS CO4 investigators can be found at http://http://www.ccde.fr.

Correspondence to Sylvie Lang, PhD, INSERM UMR_S 1136, Paris, 56 Bd Vincent Auriol, CS 81293, Paris Cedex 13 75646, France. Tel: +33 142164269; fax: +33 142164267; e-mail: slang@ccde.chups.jussieu.fr

Received 7 February, 2014

Revised 23 May, 2014

Accepted 23 May, 2014

© 2014 Lippincott Williams & Wilkins, Inc.