There are concerns about residual viremia in sanctuary sites among patients on protease inhibitor monotherapy, so we aimed to study viro-immunological parameters in tonsil's lymphoid tissue of patients on highly active antiretroviral therapy (HAART) and on protease inhibitor monotherapy. Despite fully suppressed serum HIV viral load, we found viral replication in both groups; in addition, more patients had detectable proviral DNA among those on HAART, compared to those on protease inhibitor monotherapy (P = 0.08), supporting the absence of a deleterious effect of protease inhibitor monotherapy.
aService of Infectious Diseases
bService of Microbiology, Hospital Universitario San Cecilio, Granada, Spain.
Correspondence to Jorge Parra-Ruiz, MD, PhD, Servicio de Enfermedades Infecciosas, Hospital Universitario San Cecilio, Avda. Dr Olóriz 16, 18012 Granada, Spain. Tel: +34 958 023 104; fax: +34 958 249 079; e-mail: email@example.com
Received 23 February, 2014
Revised 15 April, 2014
Accepted 16 April, 2014