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HIV-1 superinfection with a triple-class drug-resistant strain in a patient successfully controlled with antiretroviral treatment

Castro, Erikaa,c; Zhao, Hongb; Cavassini, Matthiasa; Mullins, James I.b; Pantaleo, Giuseppec; Bart, Pierre-Alexandrec,d

doi: 10.1097/QAD.0000000000000342
Research Letters

We report a case of HIV-1 superinfection (HSI) with a clade B, triple-class resistant virus in a patient successfully controlling viremia with continuous combination antiretroviral therapy started 8 years earlier during primary HIV infection. The course of HIV infection prior to HSI was monitored in both the source partner and recipient (8 and 11 years, respectively) and 4 years following HSI. This case report demonstrates re-infection with HIV-1 despite effective combination antiretroviral therapy.

aService of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

bDepartments of Microbiology, Medicine and Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA

cLaboratory of AIDS Immunopathogenesis, Service of Immunology and Allergy

dService of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Correspondence to Erika Castro, Addiction Medicine Unit Saint Martin, Service of Community Psychiatry, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Rue Saint-Martin 7, 1003 Lausanne, Switzerland. E-mail:

Received 28 March, 2014

Revised 5 May, 2014

Accepted 6 May, 2014

© 2014 Lippincott Williams & Wilkins, Inc.