We investigated the relationship between the size of blood HIV reservoirs and T-cell activation in patients with primary HIV infection (PHI) and chronic HIV infection (CHI) before and after antiretroviral therapy (ART) interruption. Levels of T-cell activation strongly positively correlated with HIV-DNA levels in viremic PHI and CHI patients. In ART-treated CHI patients, residual immune activation was not associated with HIV-DNA levels. Interestingly, early levels of HIV-DNA in PHI predicted the extent of residual T-cell proliferation under ART.
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aUniversité Paris Descartes, Sorbonne Paris Cité
bInstitut Pasteur, Régulation des infections rétrovirales
cAP-HP Hôpital Européen Georges Pompidou
dUniversité Paris Diderot, Sorbonne Paris Cité
fUniversité Pierre et Marie Curie
gAP-HP Hôpital Saint-Antoine
hUniversité Paris Descartes, EA 3620, Paris, France.
*Present address: Urology Research Unit, Lausanne University Hospital, Lausanne, Switzerland.
Correspondence to Laurence Weiss, MD, PhD, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France. Tel: +33 156 093 297; fax: +33 156 093 026; e-mail: firstname.lastname@example.org.
Received 24 October, 2013
Revised 22 April, 2014
Accepted 24 April, 2014
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