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T-cell activation positively correlates with cell-associated HIV-DNA level in viremic patients with primary or chronic HIV-1 infection

Weiss, Laurencea,b,c; Chevalier, Mathieu F.b,d,*; Assoumou, Lamberte,f; Didier, Célineb; Girard, Pierre-Marieg; Piketty, Christophec; Costagliola, Dominiquee,f; Rouzioux, Christinehthe ANRS 116 SALTO Study Group

doi: 10.1097/QAD.0000000000000319
Research Letters

We investigated the relationship between the size of blood HIV reservoirs and T-cell activation in patients with primary HIV infection (PHI) and chronic HIV infection (CHI) before and after antiretroviral therapy (ART) interruption. Levels of T-cell activation strongly positively correlated with HIV-DNA levels in viremic PHI and CHI patients. In ART-treated CHI patients, residual immune activation was not associated with HIV-DNA levels. Interestingly, early levels of HIV-DNA in PHI predicted the extent of residual T-cell proliferation under ART.

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aUniversité Paris Descartes, Sorbonne Paris Cité

bInstitut Pasteur, Régulation des infections rétrovirales

cAP-HP Hôpital Européen Georges Pompidou

dUniversité Paris Diderot, Sorbonne Paris Cité

eINSERM U943

fUniversité Pierre et Marie Curie

gAP-HP Hôpital Saint-Antoine

hUniversité Paris Descartes, EA 3620, Paris, France.

*Present address: Urology Research Unit, Lausanne University Hospital, Lausanne, Switzerland.

Correspondence to Laurence Weiss, MD, PhD, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France. Tel: +33 156 093 297; fax: +33 156 093 026; e-mail: laurence.weiss@egp.aphp.fr.

Received 24 October, 2013

Revised 22 April, 2014

Accepted 24 April, 2014

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com).

© 2014 Lippincott Williams & Wilkins, Inc.