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T-cell activation positively correlates with cell-associated HIV-DNA level in viremic patients with primary or chronic HIV-1 infection

Weiss, Laurencea,b,c; Chevalier, Mathieu F.b,d,*; Assoumou, Lamberte,f; Didier, Célineb; Girard, Pierre-Marieg; Piketty, Christophec; Costagliola, Dominiquee,f; Rouzioux, Christinehthe ANRS 116 SALTO Study Group

doi: 10.1097/QAD.0000000000000319
Research Letters

We investigated the relationship between the size of blood HIV reservoirs and T-cell activation in patients with primary HIV infection (PHI) and chronic HIV infection (CHI) before and after antiretroviral therapy (ART) interruption. Levels of T-cell activation strongly positively correlated with HIV-DNA levels in viremic PHI and CHI patients. In ART-treated CHI patients, residual immune activation was not associated with HIV-DNA levels. Interestingly, early levels of HIV-DNA in PHI predicted the extent of residual T-cell proliferation under ART.

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aUniversité Paris Descartes, Sorbonne Paris Cité

bInstitut Pasteur, Régulation des infections rétrovirales

cAP-HP Hôpital Européen Georges Pompidou

dUniversité Paris Diderot, Sorbonne Paris Cité


fUniversité Pierre et Marie Curie

gAP-HP Hôpital Saint-Antoine

hUniversité Paris Descartes, EA 3620, Paris, France.

*Present address: Urology Research Unit, Lausanne University Hospital, Lausanne, Switzerland.

Correspondence to Laurence Weiss, MD, PhD, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France. Tel: +33 156 093 297; fax: +33 156 093 026; e-mail:

Received 24 October, 2013

Revised 22 April, 2014

Accepted 24 April, 2014

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© 2014 Lippincott Williams & Wilkins, Inc.