Share this article on:

SLC30A8 rs13266634 polymorphism is related to a favorable cardiometabolic lipid profile in HIV/hepatitis C virus-coinfected patients

Pineda-Tenor, Daniela; Micheloud, Darielab; Berenguer, Juanc,d; Jiménez-Sousa, María A.a; Fernández-Rodríguez, Amandaa; García-Broncano, Pilara; Guzmán-Fulgencio, Maríaa; Diez, Cristinac,d; Bellón, José M.e; Carrero, Anac,d; Aldámiz-Echevarria, Teresac,d; García-Álvarez, Mónicaa; Resino, Salvadora

doi: 10.1097/QAD.0000000000000215
Clinical Science: Concise Communications

Objective: To analyze the relationship of SLC30A8 rs13266634 polymorphism with insulin resistance and dyslipidemia in HIV/hepatitis C virus (HCV)-coinfected patients.

Design: Cross-sectional study in 260 HIV/HVC-coinfected patients.

Methods: SLC30A8 polymorphisms were genotyped by GoldenGate assay. Genetic data were analyzed under the dominant inheritance model (CT/TT versus CC). Cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), LDL-C/HDL-C, atherogenic index, and homeostatic model assessment of insulin resistance (HOMA-IR) values were assayed for each genotype.

Results: rs13266634 CT/TT carriers had higher serum values of HDL-C (P = 0.014) and lower values of LDL-C/HDL-C (P = 0.036) and atherogenic index (P = 0.011) than CC carriers. Additionally, rs13266634 CT/TT carriers had lower percentage of HDL 35 mg/dl or less (P = 0.050) and higher percentage of LDL/HDL at least 3 (P = 0.091) and atherogenic index at least 3.5 (P = 0.003) than CC carriers. When adjusted regression analysis was performed, rs13266634 CT/TT genotype was associated with high serum values of HDL-C [arithmetic mean ratio (AMR) = 1.10 (95% confidence interval, CI = 1.03–1.19) P = 0.006], and low values of LDL-C/HDL-C [AMR = 0.88 (95% CI = 0.79–0.99) P = 0.045] and atherogenic index [AMR = 0.89 (95% CI = 0.81–0.98) P = 0.024]. For categorical outcomes, rs13266634 CT/TT carriers had lower significant likelihood of having atherogenic index at least 3.5 [odds ratio = 0.47 (95% CI = 0.26–0.83) P = 0.009], and very close to significance for LDL-C/HDL-C at least 3 [odds ratio = 0.52 (95% CI = 0.27–1.02) P = 0.056], supporting the protective effect of the CT/TT genotypes. No significant relationship was observed between rs13266634 and HOMA-IR values.

Conclusion: rs13266634 CT/TT genotype was associated to higher levels of HDL-C and lower values of cardiovascular risk indices (LDL-C/HDL-C and atherogenic index), but there was a lack of association with HOMA-IR values. Thus, rs13266634 polymorphism might play a significant role in lipid metabolism and cardiovascular risk in HIV/HCV-coinfected patients.

aUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda

bServicio de Medicina Interna

cUnidad de Enfermedades Infecciosas/VIH, Hospital General Universitario ‘Gregorio Marañón’

dInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM)

eFundación para la Investigación Biomédica, Hospital General Universitario ‘Gregorio Marañón’, Madrid, Spain.

Correspondence to Salvador Resino, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Carretera Majadahonda-Pozuelo, Km 2.2, 28220 Majadahonda, Madrid, Spain. Tel: +34 918 223 266; fax: +34 918 223 269; e-mail: sresino@isciii.es

Received 29 November, 2013

Revised 15 January, 2014

Accepted 15 January, 2014

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com).

© 2014 Lippincott Williams & Wilkins, Inc.