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Immunologic status and virologic outcomes in repeat pregnancies to HIV-positive women not on antiretroviral therapy at conception: a case for lifelong antiretroviral therapy?

French, Clare E.a; Thorne, Clairea; Tariq, Shemab; Cortina-Borja, Marioa; Tookey, Pat A.a

AIDS:
doi: 10.1097/QAD.0000000000000282
Research Letter
Abstract

During their second pregnancy with diagnosed HIV (n = 1177), two-fifths of women in the UK/Ireland not on antiretroviral therapy (ART) at conception had an immunological indication for treatment (CD4+ <350 cells/μl), of whom nearly half had CD4+ at least 350 cells/μl in their previous pregnancy. Those initiating ART during pregnancy had a 4.3-fold increased odds of detectable viral load at delivery compared with those conceiving on treatment, suggesting that continuation of ART after pregnancy may be beneficial for many women.

Author Information

aPopulation, Policy and Practice Programme, UCL Institute of Child Health, University College London, UK

bSchool of Health Sciences, City University London, UK.

Correspondence to Clare E. French, BSc, MSc, Population, Policy and Practice Programme, UCL Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK. E-mail: clare.french.09@ucl.ac.uk

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.

Received February 6, 2014

Accepted March 11, 2014

© 2014 Lippincott Williams & Wilkins, Inc.