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Innate immunity cell activation in virologically suppressed HIV-infected maraviroc-treated patients

Dentone, Chiaraa,b; Di Biagio, Antonioc; Parodi, Alessiab; Bozzano, Federicab,d; Fraccaro, Paoloe; Signori, Alessiof; Cenderello, Giovannig; Mantia, Eugenioh; Orofino, Giancarloi; De Maria, Andreab,c,j; Filaci, Gilbertob,k; Fenoglio, Danielab,k

doi: 10.1097/QAD.0000000000000194
Research Letter

This is a cross-sectional, case–control study analyzing the effect of antiretroviral therapy (ART) including or not maraviroc, on circulating monocytes and natural killer cells. Sixty-eight HIV-positive patients virologically suppressed receiving ART at least 6 months were subdivided as receiving (group 1) or not (group 2) maraviroc in their ART. Frequency of monocytes and natural killer cells, as well as their activation markers, were studied. Modulation of innate immune cells may be differently affected by combined ART.

aInfectious Diseases Department, Sanremo Hospital, Sanremo

bCenter of Excellence for Biomedical Research (CEBR), University of Genoa

cInfectious Diseases Department, IRCCS San Martino Hospital

dDIMES Department of Experimental Medicine

eDepartment of Informatics, Bioengineering, Robotic and System Engineering (DIBRIS)

fSection of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa

gInfectious Diseases Department, Galliera Hospital, Genoa

hInfectious Diseases Department, SS. Antonio, Biagio, Cesare Arrigo Hospital, Alessandria

iInfectious Diseases Department, Amedeo di Savoia Hospital, Turin


kDepartment of Internal Medicine (DIMI), University of Genoa, Genoa, Italy.

Correspondence to Chiara Dentone, MD, Infectious Diseases Department, Sanremo Hospital, Via Borea, 36 18038 Sanremo, Imperia, Italy. Tel: +39 0184536844; e-mail:

Received 10 August, 2013

Revised 6 January, 2014

Accepted 6 January, 2014

© 2014 Lippincott Williams & Wilkins, Inc.