This is a cross-sectional, case–control study analyzing the effect of antiretroviral therapy (ART) including or not maraviroc, on circulating monocytes and natural killer cells. Sixty-eight HIV-positive patients virologically suppressed receiving ART at least 6 months were subdivided as receiving (group 1) or not (group 2) maraviroc in their ART. Frequency of monocytes and natural killer cells, as well as their activation markers, were studied. Modulation of innate immune cells may be differently affected by combined ART.
aInfectious Diseases Department, Sanremo Hospital, Sanremo
bCenter of Excellence for Biomedical Research (CEBR), University of Genoa
cInfectious Diseases Department, IRCCS San Martino Hospital
dDIMES Department of Experimental Medicine
eDepartment of Informatics, Bioengineering, Robotic and System Engineering (DIBRIS)
fSection of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa
gInfectious Diseases Department, Galliera Hospital, Genoa
hInfectious Diseases Department, SS. Antonio, Biagio, Cesare Arrigo Hospital, Alessandria
iInfectious Diseases Department, Amedeo di Savoia Hospital, Turin
kDepartment of Internal Medicine (DIMI), University of Genoa, Genoa, Italy.
Correspondence to Chiara Dentone, MD, Infectious Diseases Department, Sanremo Hospital, Via Borea, 36 18038 Sanremo, Imperia, Italy. Tel: +39 0184536844; e-mail: firstname.lastname@example.org
Received 10 August, 2013
Revised 6 January, 2014
Accepted 6 January, 2014