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doi: 10.1097/QAD.0000000000000101
Basic Science

Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals

Esbjörnsson, Joakima,b,c,d; Månsson, Fredrike; Kvist, Andersf; Isberg, Per-Erikg; Biague, Antonio J.h; da Silva, Zacarias J.h; Jansson, Mariannec,i; Fenyö, Eva Mariai; Norrgren, Hansj; Medstrand, Patrika

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Objective: To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals.

Design: Prospective open cohort study.

Methods: We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (∼20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model.

Results: Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had a more than two-fold lower mortality risk during follow-up than HIV-1 single-infected individuals.

Conclusion: Survival time is longer and the risk of progression to death is lower among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals. This natural inhibition could have implications for the development of future HIV-1 vaccines and therapeutics.

© 2014 Lippincott Williams & Wilkins, Inc.


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