To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals.
Prospective open cohort study.
We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (∼20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model.
Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had a more than two-fold lower mortality risk during follow-up than HIV-1 single-infected individuals.
Survival time is longer and the risk of progression to death is lower among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals. This natural inhibition could have implications for the development of future HIV-1 vaccines and therapeutics.
Supplemental Digital Content is available in the text
aDepartment of Laboratory Medicine Malmö, Lund University, Malmö, Sweden
bNuffield Department of Medicine, NDM Research building, University of Oxford, Oxford, UK
cDepartment of Microbiology, Tumor and Cell biology (MTC), Karolinska Institute, Stockholm, Sweden
dREGA Institute, Katholieke Universiteit, Leuven, Belgium
eDepartment of Clinical Sciences Malmö, Lund University, Malmö
fDepartment of Clinical Sciences Lund, Division of Oncology
gDepartment of Statistics, Lund University School of Economics and Management, Lund University, Lund, Sweden
hNational Public Health Laboratory, Bissau, Guinea-Bissau
iDepartment of Laboratory Medicine Lund
jDepartment of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden.
Correspondence to Joakim Esbjörnsson, Department of Laboratory Medicine Malmö, Lund University, BMC C13, 221 84 Lund, Sweden. E-mail: firstname.lastname@example.org
Received 26 September, 2013
Revised 16 December, 2013
Accepted 18 December, 2013
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com).