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Specific loss of cellular L-selectin on CD4+ T cells is associated with progressive multifocal leukoencephalopathy development during HIV infection

Schneider-Hohendorf, Tilman; Philipp, Konstanze; Husstedt, Ingo W.; Wiendl, Heinz; Schwab, Nicholas

doi: 10.1097/QAD.0000000000000201
Research Letters

HIV+ progressive multifocal leukoencephalopathy (PML) patients had a significantly lower expression of CD62L on CD4+ T cells (P < 0.001) when compared with HIV+ patients who did not develop PML. CD62L expression on CD4+ T cells did not correlate with parameters such as CDC stage, CD4+ cell percentage (of total CD3+ T cells), CD4+ cell counts, virus count, or clinical parameters. Measurement of CD62L might provide a biomarker for PML risk and could prompt a treatment change and/or close monitoring.

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Department of Neurology, University of Münster, Münster, Germany.

Correspondence to Dr Tilman Schneider-Hohendorf, Department of Neurology, University of Münster, Albert-Schweitzer-Campus-1, Building A01, 48149 Münster, Germany. Tel: +49 251 980 2885; e-mail:

Received 10 December, 2013

Revised 6 January, 2014

Accepted 6 January, 2014

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© 2014 Lippincott Williams & Wilkins, Inc.