Skip Navigation LinksHome > March 13, 2014 - Volume 28 - Issue 5 > Antiretrovirals and the kidney in current clinical practice:...
Text sizing:
A
A
A
AIDS:
doi: 10.1097/QAD.0000000000000103
Editorial Reviews

Antiretrovirals and the kidney in current clinical practice: renal pharmacokinetics, alterations of renal function and renal toxicity

Yombi, Jean C.a,b; Pozniak, Antonb; Boffito, Martab; Jones, Rachaelb; Khoo, Sayec; Levy, Jeremyd; Post, Frank A.e

Collapse Box

Abstract

Assessment of renal function in HIV-positive patients is of increasing importance in the context of ageing and associated comorbidities. Exposure to nephrotoxic medications is widespread, and several commonly used antiretroviral drugs have nephrotoxic potential. Moreover, specific antiretrovirals inhibit renal tubular transporters resulting in the potential for drug–drug interactions as well as increases in serum creatinine concentrations, which affect estimates of glomerular filtration rate in the absence of changes in actual glomerular filtration rate. This review explores the effects of antiretroviral therapy on the kidney and offers an understanding of mechanisms that lead to apparent and real changes in renal function.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.