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AIDS:
doi: 10.1097/QAD.0000000000000065
Clinical Science: Concise Communication

HIV-1 seroreversion in HIV-1-infected children: do genetic determinants play a role?

Asang, Corinnaa; Laws, Hans-J.a; Adams, Ortwinb; Enczmann, Jürgenc; Feiterna-Sperling, Corneliad; Notheis, Gundulae; Buchholz, Berndf; Borkhardt, Arndta; Neubert, Jennifera

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Abstract

Background:

HIV-1 seroreversion in infants with vertically transmitted HIV-1 infection who started ART in the first months of life has been reported in only a subset of patients. However, the reason why most infants remain seropositive despite similar treatment response is not understood. Here, we assessed whether HIV-1 seroreversion in maternally infected infants is associated with genetic determinants.

Methods:

HIV-1-infected infants with a history of documented HIV-1 seroreversion were identified throughout Germany using a standardized questionnaire. At study entry immune reconstitution and anti-HIV-1 antibody expression were monitored as clinical parameters. To search for genetic determinants high-resolution HLA genotyping was performed. In addition, the coding sequence of the chemokine receptor CCR5 was analyzed by Sanger sequencing regarding potential mutations.

Results:

Patients showed normal numbers and frequencies of lymphocyte subpopulations. Five out of eight patients still had seronegative HIV-1 antibody status at study entry. HLA genotyping revealed the enrichment of HLA-DQB1∗03 and DQB1∗06 alleles within the patient cohort. Only one patient was found to carry a 32 bp-deletion within the CCR5 gene.

Conclusion:

Our results indicate that the phenotype of HIV-1 seroreversion in infants might correlate with the presence of HLA class II alleles DQB1∗03 and DQB1∗06. This finding supports the idea of genetic predisposition determining HIV-1 seroreversion in vertically infected infants effectively treated with ART.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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