Skip Navigation LinksHome > February 20, 2014 - Volume 28 - Issue 4 > Generic antiretroviral drugs in developing countries: frien...
doi: 10.1097/QAD.0000000000000170
Research Letters

Generic antiretroviral drugs in developing countries: friends or foes?

Zucman, Davida; Camara, Seydoua; Gravisse, Jéromea; Dimi, Svetlanea; Vasse, Marca; Goudjo, Abdonb; Choquet, Marionc; Peytavin, Gillesc

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Although second-line generic antiretroviral drugs are of great value in developing countries, there are concerns regarding their quality. We studied a generic Lopinavir/ritonavir (200/50 mg; Arga-L, India) marketed in the Republic of Congo but not prequalified by WHO. Despite adequate quantitative and qualitative drug content, Arga-L had a bio-availablility of 10% compared with Kaletra. To avoid selection of drug-resistant HIV, rigorous pharmacological monitoring of generic drugs not prequalified by WHO must be a priority.

Copyright © 2014 Wolters Kluwer Health, Inc.


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