Lower peak bone mass and abnormal trabecular and cortical microarchitecture in young men infected with HIV early in life

Yin, Michael T.a; Lund, Emilya; Shah, Jayesha; Zhang, Chiyuan A.a; Foca, Marca; Neu, Nataliea; Nishiyama, Kyle K.a; Zhou, Binb; Guo, Xiangdong E.b; Nelson, John; Bell, David L.a; Shane, Elizabetha; Arpadi, Stephen M.a

AIDS:
doi: 10.1097/QAD.0000000000000070
Clinical Science
Abstract

Introduction: HIV infection and antiretroviral therapy (ART) early in life may interfere with acquisition of peak bone mass, thereby increasing fracture risk in adulthood.

Methods: We conducted a cross-sectional study of dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) in 30 HIV-infected African–American or Hispanic Tanner stage 5 men aged 20–25 on ART (15 perinatally infected and 15 infected during adolescence) and 15 HIV-uninfected controls.

Results: HIV-infected men were similar in age and BMI, but were more likely to be African–American (P = 0.01) than uninfected men. DXA-derived areal bone mineral density (aBMD) Z-scores were 0.4–1.2 lower in HIV-infected men at the spine, hip, and radius (all P < 0.05). At the radius and tibia, total and trabecular volumetric BMD (vBMD), and cortical and trabecular thickness were between 6 and 19% lower in HIV-infected than uninfected men (P <0.05). HIV-infected men had dramatic deficiencies in plate-related parameters by individual trabeculae segmentation (ITS) analyses and 14–17% lower bone stiffness by finite element analysis. Differences in most HR-pQCT parameters remained significant after adjustment for race/ethnicity. No DXA or HR-pQCT parameters differed between men infected perinatally or during adolescence.

Conclusion: At an age by which young men have typically acquired peak bone mass, HIV-infected men on ART have lower BMD, markedly abnormal trabecular plate and cortical microarchitecture, and decreased whole bone stiffness, whether infected perinatally or during adolescence. Reduced bone strength in young adults infected with HIV early in life may place them at higher risk for fractures as they age.

Author Information

aColumbia University Medical Center

bBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA.

Correspondence to Michael T. Yin, MD, MS, Division of Infectious Diseases, Columbia University Medical Center, 630 West 168th street, PH8-876, New York, NY 10032, USA. Tel: +1 212 305 7185; fax: +1 212 305 7290; e-mail: Mty4@columbia.edu

Received 24 June, 2013

Accepted 5 September, 2013

© 2014 Lippincott Williams & Wilkins, Inc.