Skip Navigation LinksHome > January 14, 2014 - Volume 28 - Issue 2 > CD4+ cell count, viral load, and drug resistance patterns am...
doi: 10.1097/QAD.0000000000000102
Clinical Science: Concise Communication

CD4+ cell count, viral load, and drug resistance patterns among heterosexual breakthrough HIV infections in a study of oral preexposure prophylaxis

Chirwa, Lovemore I.a; Johnson, Jeffrey A.b; Niska, Richard W.b; Segolodi, Tebogo M.a; Henderson, Faith L.b; Rose, Charles E.b; Li, Jin-fenb; Thigpen, Michael C.b; Matlhaba, Onkabetsea; Paxton, Lynn A.b; Brooks, John T.b

Collapse Box


We examined CD4+ cell count and plasma viral load patterns among Botswana TDF/FTC Oral HIV Prophylaxis Trial (TDF2 study) participants who seroconverted, comparing participants assigned to receive tenofovir/emtricitabine with participants assigned to receive placebo. We also evaluated for antiretroviral drug resistance among the breakthrough HIV infections. Among nine seroconverters assigned to tenofovir/emtricitabine and 24 to placebo, there were no significant differences in their CD4+ cell count or viral load profiles over time. Of the four participants who seroconverted on-study while receiving tenofovir/emtricitabine, none became infected as a result of drug-resistant HIV; moreover, no resistance mutations emerged following seroconversion.

© 2014 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.