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AIDS:
doi: 10.1097/QAD.0000000000000043
Research Letters

HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes

Kennedy, Alana; Petrasca, Andreeab; Doherty, Derek G.b; Hennessy, Martinaa; Spiers, J. Paula

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Abstract

HIV-1 Tat exhibits clade-specific cytokine induction in monocytes. We investigated if Tat clades A-D can alter tumour necrosis factor (TNF)-α and interferon (IFN)-γ production by total and Vγ9Vδ2 T cells in vitro. Tat clade B, but not C, augmented TNF-α production by THP-1 cells. However, Tat clades A-D did not affect TNF-α or IFN-γ production or secretion by resting or activated conventional and Vγ9Vδ2 T cells. Therefore, transactivation of cytokines by Tat is immune cell-specific.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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