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HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes

Kennedy, Alana; Petrasca, Andreeab; Doherty, Derek G.b; Hennessy, Martinaa; Spiers, J. Paula

doi: 10.1097/QAD.0000000000000043
Research Letters

HIV-1 Tat exhibits clade-specific cytokine induction in monocytes. We investigated if Tat clades A-D can alter tumour necrosis factor (TNF)-α and interferon (IFN)-γ production by total and Vγ9Vδ2 T cells in vitro. Tat clade B, but not C, augmented TNF-α production by THP-1 cells. However, Tat clades A-D did not affect TNF-α or IFN-γ production or secretion by resting or activated conventional and Vγ9Vδ2 T cells. Therefore, transactivation of cytokines by Tat is immune cell-specific.

aDepartment of Pharmacology and Therapeutics

bDepartment of Immunology, School of Medicine, Trinity College Dublin, Ireland.

Correspondence to J. Paul Spiers, Associate Professor, Department of Pharmacology and Therapeutics, Trinity College Dublin, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland. Tel: +353 1 8962146; fax: +353 1 4539033; e-mail:

Received 21 August, 2013

© 2014 Lippincott Williams & Wilkins, Inc.