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AIDS:
doi: 10.1097/01.aids.0000433234.78807.54
Research Letters

Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C

Krämer, Benjamina,∗; Nischalke, Hans Dietera,∗; Boesecke, Christopha; Ingiliz, Patrickb; Voigt, Estherc; Mauss, Stefand; Stellbrink, Hans-Jürgene; Baumgarten, Axelb; Rockstroh, Juergen K.a; Spengler, Ulricha; Nattermann, Jacoba

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Abstract

The IFNL4 ss469415590 polymorphism has recently be shown to better predict treatment response in chronic hepatitis than the IL28B rs12979860 variant. However, no data exist in patients with HIV/hepatitis C virus (HCV) coinfection. Analysing 206 HCV(+)/HIV(+) and 162 HCV(+)/HIV(−) patients, we found that compared with IL28B rs12979860, IFNL4 ss469415590 was strongly associated with response to interferon/ribavirin therapy in HCV(+)/HIV(−) individuals but not in HIV(+)/HCV(+) patients. Thus, effects of the IFNL4 variant may differ in HIV(+) and HIV(−) patients.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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