Hepatitis C virus reinfection incidence and treatment outcome among HIV-positive MSM

Martin, Thomas C.S.a; Martin, Natasha K.b,c; Hickman, Matthewb; Vickerman, Peterc; Page, Emma E.a; Everett, Rhiannona; Gazzard, Brian G.a; Nelson, Marka

AIDS:
doi: 10.1097/QAD.0b013e32836381cc
Clinical Science
Abstract

Objective: Liver disease secondary to hepatitis C virus (HCV) infection in the context of HIV infection is one of the leading non-AIDS causes of death. Sexual transmission of HCV infection among HIV-positive MSM appears to be leading to increased reports of acute HCV infection. Reinfection after successful treatment or spontaneous clearance is reported among HIV-positive MSM but the scale of reinfection is unknown. We calculate and compare HCV reinfection rates among HIV-positive MSM after spontaneous clearance and successful medical treatment of infection.

Design: Retrospective analysis of HIV-positive MSM with sexually acquired HCV who subsequently spontaneously cleared or underwent successful HCV treatment between 2004 and 2012.

Results: Among 191 individuals infected with HCV, 44 were reinfected over 562 person-years (py) of follow-up with an overall reinfection rate of 7.8/100 py [95% confidence interval (CI) 5.8–10.5]. Eight individuals were subsequently reinfected a second time at a rate of 15.5/100 py (95% CI 7.7–31.0). Combining all reinfections, 20% resulted in spontaneous clearance and treatment sustained viral response rates were 73% (16/22) for genotypes one and four and 100% (2/2) for genotypes two and three. Among 145 individuals with a documented primary infection, the reinfection rate was 8.0 per 100 py (95% CI 5.7–11.3) overall, 9.6/100 py (95% CI 6.6–14.1) among those successfully treated and 4.2/100 py (95% CI 1.7–10.0) among those who spontaneously cleared. The secondary reinfection rate was 23.2/100 py (95% CI 11.6–46.4).

Conclusion: Despite efforts at reducing risk behaviour, HIV-positive MSM who clear HCV infection remain at high risk of reinfection. This emphasizes the need for increased sexual education, surveillance and preventive intervention work.

Author Information

aHIV Department, Chelsea and Westminster Hospital, London

bSchool of Social and Community Medicine, University of Bristol, Bristol

cSocial and Mathematical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.

Correspondence to Thomas C.S. Martin. Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK. E-mail: thomas.martin@cantab.net

Received 9 March, 2013

Revised 21 May, 2013

Accepted 21 May, 2013

© 2013 Lippincott Williams & Wilkins, Inc.