Skip Navigation LinksHome > September 24, 2013 - Volume 27 - Issue 15 > Natural NS3 resistance polymorphisms occur frequently prior...
AIDS:
doi: 10.1097/QAD.0b013e328363b1f9
Research Letters

Natural NS3 resistance polymorphisms occur frequently prior to treatment in HIV-positive patients with acute hepatitis C

Leggewie, Maykea; Sreenu, Vattipally B.a; Abdelrahman, Tamera; M. Leitch, E. Carola; Wilkie, Gavin S.a; Klymenko, Tetyanaa; Muir, Davidb; Thursz, Markc; Main, Janicec; Thomson, Emma C.a,c

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Abstract

NS3 protease inhibitors are set to improve sustained virological response rates in HIV-positive patients with hepatitis C. We measured the prevalence of natural resistance polymorphisms in 38 acutely infected treatment-naive patients using direct and deep sequencing. Twenty six percent of patients (10/38) had a majority variant resistance mutation (in order of frequency; Q80K – 16%, V36M – 5%, T54S – 3%, V55A – 3%, and D168A – 3%). Low-frequency mutations were detected in all samples. Further studies are required to determine threshold levels associated with treatment failure.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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