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Skip Navigation LinksHome > September 24, 2013 - Volume 27 - Issue 15 > Association of early HIV viremia with mortality after HIV-as...
AIDS:
doi: 10.1097/QAD.0b013e3283635232
Clinical Science

Association of early HIV viremia with mortality after HIV-associated lymphoma

Gopal, Satisha,*; Patel, Monita R.a,*; Yanik, Elizabeth L.a; Cole, Stephen R.a; Achenbach, Chad J.b; Napravnik, Soniaa; Burkholder, Greer A.c; Reid, Erin G.d; Rodriguez, Benignoe; Deeks, Steven G.f; Mayer, Kenneth H.g; Moore, Richard D.h; Kitahata, Mari M.i; Richards, Kristy L.a; Eron, Joseph J.a

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Abstract

Objective: To examine the association between early HIV viremia and mortality after HIV-associated lymphoma.

Design: Multicenter observational cohort study.

Setting: Center for AIDS Research Network of Integrated Clinical Systems cohort.

Participants: HIV-infected patients with lymphoma diagnosed between 1996 and 2011, who were alive 6 months after lymphoma diagnosis and with at least two HIV RNA values during the 6 months after lymphoma diagnosis.

Exposure: Cumulative HIV viremia during the 6 months after lymphoma diagnosis, expressed as viremia copy-6-months.

Main outcome measure: All-cause mortality between 6 months and 5 years after lymphoma diagnosis.

Results: Of 224 included patients, 183 (82%) had non-Hodgkin lymphoma (NHL) and 41 (18%) had Hodgkin lymphoma. At lymphoma diagnosis, 105 (47%) patients were on antiretroviral therapy (ART), median CD4+ cell count was 148 cells/μl (interquartile range 54–322), and 33% had suppressed HIV RNA (<400 copies/ml). In adjusted analyses, mortality was associated with older age [adjusted hazard ratio (AHR) 1.37 per decade increase, 95% CI 1.03–1.83], lymphoma occurrence on ART (AHR 1.63, 95% CI 1.02–2.63), lower CD4+ cell count (AHR 0.75 per 100 cells/μl increase, 95% CI 0.64–0.89), and higher early cumulative viremia (AHR 1.35 per log10copies × 6-months/ml, 95% CI 1.11–1.65). The detrimental effect of early cumulative viremia was consistent across patient groups defined by ART status, CD4+ cell count, and histology.

Conclusion: Exposure to each additional 1-unit log10 in HIV RNA throughout the 6 months after lymphoma diagnosis was associated with a 35% increase in subsequent mortality. These results suggest that early and effective ART during chemotherapy may improve survival.

© 2013 Lippincott Williams & Wilkins, Inc.

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