Skip Navigation LinksHome > August 24, 2013 - Volume 27 - Issue 13 > Synergistic activity of carbosilane dendrimers in combinatio...
AIDS:
doi: 10.1097/QAD.0b013e328361fa4a
Basic Science: Concise Communication

Synergistic activity of carbosilane dendrimers in combination with maraviroc against HIV in vitro

Córdoba, Enrique Vacasa,b,d; Arnáiz, Eduardoc,d; De La Mata, Francisco J.c,d; Gómez, Rafaelc,d; Leal, Manuele; Pion, Marjoriea,b,d; Muñoz-Fernández, Ma Ángelesa,b,d

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Abstract

Objective:

Dendrimers have been shown as effective and safe anti-HIV compounds with great potential as topical microbicides. Currently, the most advanced microbicides are based on antiretrovirals. However, nowadays none of them has shown any success in clinical trials.

Design:

Antiviral activity and combinatorial profile of different combinations between CCR5 co-receptor antagonist, maraviroc (MRV), and polyanionic carbosilane dendrimers against HIV-1 strains were evaluated.

Methods:

Cellular in-vitro models were used to evaluate the antiviral action of combinations of carbosilane dendrimers/MRV against CCR5 and dual tropic viral strains in TZM.bl cells and peripheral blood mononuclear cells. Combinatorial analysis was performed using Calcusyn software.

Results:

In the majority of combinations tested, dendrimers showed synergistic profile with MRV against CCR5 and dual tropic HIV-1.

Conclusion:

The evaluated two-drug combinations increase their antiviral potency supporting further clinical investigations to develop combinatorial formulated topical microbicides to fight against the worldwide HIV spread.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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