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Skip Navigation LinksHome > August 24, 2013 - Volume 27 - Issue 13 > Oral human papillomavirus infection in HIV-negative and HIV-...
AIDS:
doi: 10.1097/QAD.0b013e328362395c
Epidemiology and Social

Oral human papillomavirus infection in HIV-negative and HIV-infected MSM

Mooij, Sofie H.a,e; Boot, Hein J.b,†; Speksnijder, Arjen G.C.L.a; Stolte, Ineke G.a; Meijer, Chris J.L.M.c; Snijders, Peter J.F.c; Verhagen, Dominique W.M.d; King, Audrey J.b; de Vries, Henry J.C.a,b,f; Quint, Wim G.V.g; van der Sande, Marianne A.B.b,h; Schim van der Loeff, Maarten F.a,e

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Abstract

Objective: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM.

Design: Analysis of baseline data from a prospective cohort study.

Methods: MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay [short PCR fragment (SPF)10-PCR-DNA Enzyme Immuno Assay (DEIA)/LiPA25 system].

Results: In 2010–2011, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years [interquartile range (IQR) 34.8–47.5] and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8 and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM.

Conclusion: Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.

© 2013 Lippincott Williams & Wilkins, Inc.

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