Skip Navigation LinksHome > July 31, 2013 - Volume 27 - Issue 12 > Secretory IgA specific for MPER can protect from HIV-1 infec...
AIDS:
doi: 10.1097/QAD.0b013e3283632ea1
Research Letters

Secretory IgA specific for MPER can protect from HIV-1 infection in vitro

Benjelloun, Fahda; Dawood, Rehama; Urcuqui-Inchima, Silviob; Chanut, Blandinea; Verrier, Bernardc; Lucht, Frederica; Genin, Christaina; Paul, Stéphanea

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Abstract

This preliminary study was performed to assess the neutralization activity of anti-MPER-secretory IgA (SIgA) from parotid saliva in 88 HIV+ patients, in five exposed seronegative (ESN) and in five seronegative volunteers. 48.9% of the HIV+ patients and 100% of ESN patients showed antigp41 SIgA. 25.6% of anti-MPER SIgA from HIV+ patients and 100% from ESN patients neutralized efficiently HIV-1 primary isolate SF162 (IC 50). The neutralization activity is maintained for much lower concentrations in ESN than in HIV+ secretions.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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