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Secretory IgA specific for MPER can protect from HIV-1 infection in vitro

Benjelloun, Fahda; Dawood, Rehama; Urcuqui-Inchima, Silviob; Chanut, Blandinea; Verrier, Bernardc; Lucht, Frederica; Genin, Christaina; Paul, Stéphanea

doi: 10.1097/QAD.0b013e3283632ea1
Research Letters

This preliminary study was performed to assess the neutralization activity of anti-MPER-secretory IgA (SIgA) from parotid saliva in 88 HIV+ patients, in five exposed seronegative (ESN) and in five seronegative volunteers. 48.9% of the HIV+ patients and 100% of ESN patients showed antigp41 SIgA. 25.6% of anti-MPER SIgA from HIV+ patients and 100% from ESN patients neutralized efficiently HIV-1 primary isolate SF162 (IC 50). The neutralization activity is maintained for much lower concentrations in ESN than in HIV+ secretions.

aGIMAP EA3064, CIC CIE3 Vaccinologie, Faculté de Medecine de Saint Etienne, Université de Lyon, Lyon, France

bGrupo de Inmunovirologia-Biogenesis, Universidad de Antioquia, Antioquia, Colombia

cInstitut de Biologie et Chimie des Protéines, FRE 3310 CNRS/UCBL, Lyon, France.

Correspondence to Stéphane Paul, Groupe Immunité des Muqueuses et Agents Pathogènes, EA 3064 Faculté de Médecine de Saint-Etienne, Université de Lyon, 15 rue Ambroise Paré, 42023 Saint-Etienne cedex 02, France. E-mail: stephane.paul@chu-st-etienne.fr

Received 4 February, 2013

Revised 2 May, 2013

Accepted 10 May, 2013

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© 2013 Lippincott Williams & Wilkins, Inc.