Skip Navigation LinksHome > July 31, 2013 - Volume 27 - Issue 12 > Altered T-cell subsets in HIV-1 natural viral suppressors (e...
AIDS:
doi: 10.1097/QAD.0b013e328362dea4
Research Letters

Altered T-cell subsets in HIV-1 natural viral suppressors (elite controllers) with hepatitis C infection

Sajadi, Mohammad M.; Redfield, Robert R.; Talwani, Rohit

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Abstract

We have established a cohort of 64 Natural Viral Suppressors (NVS) (similar to Elite Controllers/Elite Suppressors), 30 of which have chronic hepatitis C virus (HCV). We investigated T-cell phenotypic changes in association with HCV infection. NVS without HCV and normal controls had similar T-cell phenotypes. However, NVS with HCV had lower naive cell proportions (CD4 and CD8) compared with NVS without HCV (P = 0.0008 and P = 0.02) or normal controls (P = 0.0163 and P = 0.017). These results and previously reported data suggest that HCV coinfection increases immune activation and T-cell disturbances. Any associated T-cell functional changes or potential clinical consequences need further study.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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