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Altered T-cell subsets in HIV-1 natural viral suppressors (elite controllers) with hepatitis C infection

Sajadi, Mohammad M.; Redfield, Robert R.; Talwani, Rohit

doi: 10.1097/QAD.0b013e328362dea4
Research Letters

We have established a cohort of 64 Natural Viral Suppressors (NVS) (similar to Elite Controllers/Elite Suppressors), 30 of which have chronic hepatitis C virus (HCV). We investigated T-cell phenotypic changes in association with HCV infection. NVS without HCV and normal controls had similar T-cell phenotypes. However, NVS with HCV had lower naive cell proportions (CD4 and CD8) compared with NVS without HCV (P = 0.0008 and P = 0.02) or normal controls (P = 0.0163 and P = 0.017). These results and previously reported data suggest that HCV coinfection increases immune activation and T-cell disturbances. Any associated T-cell functional changes or potential clinical consequences need further study.

Institute of Human Virology at the University of Maryland School of Medicine, Baltimore, Maryland, USA.

Correspondence to Mohammad M. Sajadi, MD, 725 West Lombard Street, N548, Baltimore, MD 21201, USA. Tel: +1 410 706 1779; fax: +1 410 706-1992; e-mail: msajadi@ihv.umaryland.edu

Received 15 April, 2013

Revised 24 April, 2013

Accepted 1 May, 2013

© 2013 Lippincott Williams & Wilkins, Inc.