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Skip Navigation LinksHome > July 17, 2013 - Volume 27 - Issue 11 > Urine processing impacts uric acid level in HIV-infected adu...
AIDS:
doi: 10.1097/QAD.0b013e32836146f6
Research Letters

Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy

Hotta, Mathew T.; Broderick, Erin; Wyatt, Christina M.

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Abstract

Urine specimens are valuable to investigate kidney disease and antiretroviral nephrotoxicity. We observed large rust-colored pellets in some urine specimens after overnight storage at 4oC. Testing of supernatant under varying conditions demonstrated that this phenomenon reflects supersaturation and precipitation of uric acid in samples with high uric acid concentration. Delays in processing, even with refrigeration, may decrease the sensitivity of urine uric acid testing, with implications for the evaluation of proximal tubulopathy related to tenofovir.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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