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Skip Navigation LinksHome > July 17, 2013 - Volume 27 - Issue 11 > MHC-driven HIV-1 control on the long run is not systematical...
AIDS:
doi: 10.1097/QAD.0b013e328360a4bd
Basic Science

MHC-driven HIV-1 control on the long run is not systematically determined at early times post-HIV-1 infection

Antoni, Guillemettea,b,*; Guergnon, Julienc,d,*; Meaudre, Célinec,d; Samri, Assiac,d; Boufassa, Faroudyb; Goujard, Cécileb,e; Lambotte, Oliviere,f; Autran, Brigittec,d,g; Rouzioux, Christineh; Costagliola, Dominiquei,j; Meyer, Laurencea,b,*; Theodorou, Ioannisc,d,g,*

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Abstract

Introduction: Human leukocyte antigen (HLA) class I-driven long-term protection against HIV-1 is mainly associated with HLA-B*27 and HLA-B*57. This effect is observed early after infection. Clarification needs to be established concerning the moment of action for the other HLA-B or HLA-C alleles.

Methods: HLA-B and HLA-C alleles from 111 individuals that control HIV-1 disease for over 8 years and from 747 seroconverters frequencies were compared. Also, HLA-B and HLA-C influence on early levels of plasma HIV-RNA, cellular HIV-DNA, CD4, CD8 and CD4/CD8 ratio was evaluated among the seroconverters. We performed univariate, multivariate and haplotypic analyses in order to disentangle the respective contribution of the HLA-B and HLA-C genes.

Results: The haplotypes analysis shows three patterns of protective effects of HLA-B and HLA-C alleles or haplotypes. First, the HLA B*57, HLA-B*27, HLA-B*13 and HLA-C*14 alleles, which have a strong effect on long-term disease control, also influence at least one of the early infection phenotypes. Second, HLA-B*52 has a strong effect during early time points on HIV-RNA without significant effect on the long-term control of HIV-1. Finally, the HLA-B*14-C*08 haplotype has a strong effect on the long-term protection, without influencing early viral control.

Conclusion: Our study highlighted independent effects of HLA-B and HLA-C alleles on HIV-disease progression. Furthermore, some alleles appeared to be specifically associated with either long-term control or early virological parameters, suggesting different immunological mechanisms according to the disease stages.

© 2013 Lippincott Williams & Wilkins, Inc.

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