GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16− natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.
aResearch and Medical Services, Iowa City VA Medical Center
bDepartments of Internal Medicine and Microbiology, The University of Iowa, Iowa City
cDepartment of Immunology\Microbiology, Rush University, Chicago, Illinois, USA
dUtrecht Institute of Pharmaceutical Sciences, Utrech University, The Netherlands.
Correspondence to Jack T. Stapleton, MD, SW54, GH, 200 Hawkins Drive, Iowa City, IA 52242, USA. Tel: +1 319 356 3168; fax: +1 319 356 4600; e-mail: firstname.lastname@example.org
Received 24 March, 2013
Revised 6 May, 2013
Accepted 7 May, 2013