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Skip Navigation LinksHome > July 17, 2013 - Volume 27 - Issue 11 > GB virus C infection and B-cell, natural killer cell, and mo...
doi: 10.1097/QAD.0b013e328363089f
Research Letters

GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Stapleton, Jack T.a,b; Martinson, Jeffrey A.c; Klinzman, Donnaa; Xiang, Jinhuaa,b; Desai, Seema N.c; Landay, Alanc,d

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GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16 natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.

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