Skip Navigation LinksHome > June 19, 2013 - Volume 27 - Issue 10 > The effect of antiretrovirals on Plasmodium falciparum liver...
doi: 10.1097/QAD.0b013e3283621dd4
Research Letters

The effect of antiretrovirals on Plasmodium falciparum liver stages

Hobbs, Charlotte V.a; De La Vega, Patriciab; Penzak, Scott R.c; Van Vliet, Jilliana; Krzych, Urszulab; Sinnis, Photinid; Borkowsky, Williame; Duffy, Patrick E.a

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HIV and malaria overlap geographically, but the full impact of different antiretrovirals on malaria remains poorly understood. We examined the antimalarial activity of the HIV protease inhibitors lopinavir and saquinavir and the non-nucleoside reverse transcriptase inhibitor nevirapine on Plasmodium falciparum liver stages. Our results demonstrate that the HIV PI lopinavir inhibits liver stage parasites at clinically relevant concentrations, that is, at drug levels achieved in HIV-infected patients on standard dosing regimens. Because drugs that inhibit liver stages target parasites when they are present in lower numbers, these results might have implications for eradication efforts.

© 2013 Lippincott Williams & Wilkins, Inc.


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