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AIDS:
doi: 10.1097/QAD.0b013e32835fd8a9
Research Letters

Treatment-related changes in serum lipids and inflammation: clinical relevance remains unclear. Analyses from the Women's Interagency HIV study

Parrinello, Christina M.a; Landay, Alan L.b; Hodis, Howard N.c; Gange, Stephen J.d; Norris, Philip J.e; Young, Maryf; Anastos, Kathryna,g; Tien, Phyllis C.h,i; Xue, Xiaonana; Lazar, Jasonj; Benning, Loried; Tracy, Russell P.k; Kaplan, Robert C.a

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Abstract

Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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