Treatment-related changes in serum lipids and inflammation: clinical relevance remains unclear. Analyses from the Women's Interagency HIV study

Parrinello, Christina M.a; Landay, Alan L.b; Hodis, Howard N.c; Gange, Stephen J.d; Norris, Philip J.e; Young, Maryf; Anastos, Kathryna,g; Tien, Phyllis C.h,i; Xue, Xiaonana; Lazar, Jasonj; Benning, Loried; Tracy, Russell P.k; Kaplan, Robert C.a

AIDS:
doi: 10.1097/QAD.0b013e32835fd8a9
Research Letters
Abstract

Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).

Author Information

aDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York

bDepartment of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois

cAtherosclerosis Research Unit, University of Southern California, Los Angeles, California

dDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

eBlood Systems Research Institute, University of California, San Francisco, Departments of Laboratory Medicine and Medicine, San Francisco, California

fDepartment of Medicine, Georgetown University Medical Center, Washington, District of Columbia

gDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York

hDepartment of Medicine, University of California, San Francisco

iSan Francisco Veterans Affairs Medical Center, San Francisco, California

jDepartment of Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York

kDepartments of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, Vermont, USA.

Correspondence to Robert C. Kaplan, PhD, 1300 Morris Park Avenue, Belfer 1306C, Bronx, NY 10461, USA. Tel: +1 718 430 4076; e-mail: robert.kaplan@einstein.yu.edu

Received 4 December, 2012

Accepted 5 February, 2013

© 2013 Lippincott Williams & Wilkins, Inc.