Skip Navigation LinksHome > June 1, 2013 - Volume 27 - Issue 9 > The CD4/CD8 ratio as a marker T-cell activation, senescence...
doi: 10.1097/QAD.0b013e32835faa72
Research Letters

The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults

Sainz, Talíaa,∗; Serrano-Villar, Sergioc,∗; Díaz, Lauraa,b; Tomé, María Isabel Gonzálezd; Gurbindo, María Doloresa; de José, María Isabele; Mellado, María Joséf; Ramos, José T.g; Zamora, Javierc; Moreno, Santiagoc; Muñoz-Fernández, María Ángelesa,b

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We explored the associations of the CD4/CD8 ratio with markers of immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children and adolescents. CD4/CD8 ratio inversion was associated with higher frequencies of activated, senescent and activated/exhausted CD4+and CD8+ T-cells, and a skewed T-cell phenotype from naive toward effector memory which persisted after the multivariate analysis. Thus, the CD4/CD8 ratio may identify patients with higher immunoactivation despite ART.

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