Skip Navigation LinksHome > February 20, 2013 - Volume 27 - Issue 4 > CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection
doi: 10.1097/QAD.0b013e32835b8cb3
Research Letters

CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection

Gaardbo, Julie Christine; Hartling, Hans Jakob; Thorsteinsson, Kristina; Ullum, Henrik; Nielsen, Susanne Dam

Collapse Box


CD8+ Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are not described. CD3+CD8+CD161high Tc17 cells and the production of interleukin (IL)-17 were examined in untreated and treated HIV-infected patients, HIV–hepatitis C virus co-infected patients, and healthy controls. Depletion of CD3+CD8+CD161high Tc17 cells and diminished production of IL-17 in HIV-infected patients were found. The level of Tc17 cells was associated with the CD4+ cell count in treated patients.

Copyright © 2013 Wolters Kluwer Health, Inc.


Article Tools


Article Level Metrics