Skip Navigation LinksHome > February 20, 2013 - Volume 27 - Issue 4 > CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection
doi: 10.1097/QAD.0b013e32835b8cb3
Research Letters

CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection

Gaardbo, Julie Christinea,b; Hartling, Hans Jakoba,b; Thorsteinsson, Kristinac; Ullum, Henrikb; Nielsen, Susanne Dama

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CD8+ Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are not described. CD3+CD8+CD161high Tc17 cells and the production of interleukin (IL)-17 were examined in untreated and treated HIV-infected patients, HIV–hepatitis C virus co-infected patients, and healthy controls. Depletion of CD3+CD8+CD161high Tc17 cells and diminished production of IL-17 in HIV-infected patients were found. The level of Tc17 cells was associated with the CD4+ cell count in treated patients.

© 2013 Lippincott Williams & Wilkins, Inc.


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