Proteinuria was observed in 27% of 153 patients taking tenofovir for more than 1 year. Concomitant protease inhibitor therapy and cumulative tenofovir exposure were independently associated with proteinuria in this cohort. Proteinuria was reversible in 11 of 12 patients who ceased tenofovir because of proteinuria without altering other medications. Clinicians should be aware that tenofovir can cause reversible proteinuria in patients with HIV.
aBrisbane Sexual Health and HIV Service
bQueensland University of Technology, Brisbane, Queensland, Australia.
Correspondence to Mark Denis Kelly, MBBS, Brisbane Sexual Health and HIV Service, Brisbane, Queensland, Australia. Tel: +07 38375622; fax: +07 38375672; e-mail: firstname.lastname@example.org
Received 1 February, 2012
Revised 20 July, 2012
Accepted 24 July, 2012