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AIDS:
doi: 10.1097/QAD.0b013e32835c1333
Epidemiology and Social: CONCISE COMMUNICATION

Markers of microbial translocation and risk of AIDS-related lymphoma

Marks, Morgan A.a; Rabkin, Charles S.a; Engels, Eric A.a; Busch, Evanb; Kopp, Williamc; Rager, Helenc; Goedert, James J.a; Chaturvedi, Anil K.a

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Abstract

Background: Depletion of gut-associated lymphocytes by HIV infection facilitates microbial translocation, which may contribute to non-Hodgkin lymphoma (NHL) risk via chronic immune activation and B-cell hyperstimulation.

Method: We therefore examined associations of four microbial translocation markers with subsequent NHL risk in a case–control study nested within four prospective cohort studies of HIV-infected individuals. Prediagnostic blood specimens for 56 NHL cases and 190 controls matched for age, sex, race, specimen type, cohort, and CD4+ T-cell count were tested for the endotoxin lipopolysaccharide (LPS), antiendotoxin core antibody (EndoCab), LPS-binding protein (LBP), and soluble CD14 (sCD14).

Results: Elevated levels of sCD14 were associated with significantly increased NHL risk [odds ratio (OR) 2.72 (95% confidence interval [95% CI] 1.29–5.76)]. In subgroup analyses, elevated LPS levels were also associated with significantly increased NHL risk [OR 3.24 (95% CI 1.10–9.53)]. EndoCab and LBP levels were not associated with NHL risk.

Conclusion: The association of sCD14 and LPS with NHL risk supports an etiologic role for gut microbial translocation in lymphomagenesis among HIV-infected individuals. Additional studies with larger sample sizes are needed to confirm these observations.

© 2013 Lippincott Williams & Wilkins, Inc.

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