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Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Tendeiro, Ritaa; Albuquerque, Adriana S.a; Foxall, Russell B.a; Cavaleiro, Ritaa; Soares, Rui S.a; Baptista, António P.a; Soares, Maria V.D.a; Gomes, Perpétuab,c,d; Sousa, Ana E.a

AIDS:
doi: 10.1097/QAD.0b013e32835ab234
Research Letters
Abstract

HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.

Author Information

aUnidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa

bCentro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Superior de Ciências da Saúde Egas Moniz, Caparica

cLaboratório de Biologia Molecular, Serviço de Medicina Transfusional, Centro Hospitalar Lisboa Ocidental, Hospital Egas Moniz

dCentro de Malária e Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal.

Correspondence to Ana E. Sousa, MD, PhD, Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal. Tel: +351 21 799 95 25; fax: +351 21 799 95 27; e-mail: asousa@fm.ul.pt

Received 17 July, 2012

Revised 20 September, 2012

Accepted 24 September, 2012

© 2013 Lippincott Williams & Wilkins, Inc.