AIDS

Skip Navigation LinksHome > January 14, 2013 - Volume 27 - Issue 2 > Concordance between HIV-2 genotypic coreceptor tropism predi...
AIDS:
doi: 10.1097/QAD.0b013e32835b8bbd
Research Letters

Concordance between HIV-2 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA

Visseaux, Benoita; Charpentier, Charlottea; Taieb, Audreyb; Damond, Florencea; Bénard, Antoineb; Larrouy, Lucilea; Chêne, Genevièveb; Brun-Vézinet, Françoisea; Matheron, Sophiec; Descamps, Dianec; the ANRS CO5 HIV-2 Cohort

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Abstract

In this study, assessing HIV-2 tropism among 43 paired plasma/peripheral blood mononuclear cell specimens, the concordance between proviral DNA and plasma RNA genotypic tropism prediction was 74%. All the discordances were attributable to the prediction of R5 in RNA and X4/dual-mixed in DNA. HIV-2 genotypic tropism test based on proviral DNA is a suitable tool for tropism determination in HIV-2-infected patients with low or undetectable viral load.

© 2013 Lippincott Williams & Wilkins, Inc.

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