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Skip Navigation LinksHome > July 31, 2012 - Volume 26 - Issue 12 > Replication of RYR3 gene polymorphism association with cIMT...
AIDS:
doi: 10.1097/QAD.0b013e328355359f
Research Letters

Replication of RYR3 gene polymorphism association with cIMT among HIV-infected whites

Shrestha, Sadeepa; Yan, Qib; Joseph, Gregoryc; Arnett, Donna K.a; Martinson, Jeremy J.c; Kingsley, Lawrence A.c

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Abstract

To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.

© 2012 Lippincott Williams & Wilkins, Inc.

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