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Replication of RYR3 gene polymorphism association with cIMT among HIV-infected whites

Shrestha, Sadeepa; Yan, Qib; Joseph, Gregoryc; Arnett, Donna K.a; Martinson, Jeremy J.c; Kingsley, Lawrence A.c

doi: 10.1097/QAD.0b013e328355359f
Research Letters

To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.

aDepartment of Epidemiology

bDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama

cDepartment of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Correspondence to Sadeep Shrestha, PhD, MHS, MS, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 217L, Birmingham, AL 35294-0022, USA. E-mail:

Received 17 October, 2011

Revised 13 April, 2012

Accepted 25 April, 2012

© 2012 Lippincott Williams & Wilkins, Inc.