To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.
aDepartment of Epidemiology
bDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama
cDepartment of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Correspondence to Sadeep Shrestha, PhD, MHS, MS, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 217L, Birmingham, AL 35294-0022, USA. E-mail: firstname.lastname@example.org
Received 17 October, 2011
Revised 13 April, 2012
Accepted 25 April, 2012