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Skip Navigation LinksHome > April 24, 2012 - Volume 26 - Issue 7 > Lower than expected maraviroc concentrations in cerebrospina...
AIDS:
doi: 10.1097/QAD.0b013e328351f627
Research Letters

Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration

Croteau, Davida; Best, Brookie M.c,e; Letendre, Scottb; Rossi, Steven S.c; Ellis, Ronald J.a; Clifford, David B.f; Collier, Ann C.g; Gelman, Benjamin B.h; Mcarthur, Justin C.i; McCutchan, John Allenb; Morgello, Susanj; Grant, Igord; for the CHARTER Group

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Abstract

To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse-phase high-performance liquid chromatography with tandem mass spectrometry, whereas ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4 ng/ml. CSF concentrations exceeded the 50% inhibitory concentration of wild-type CC chemokine receptor 5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF.

© 2012 Lippincott Williams & Wilkins, Inc.

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