CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus.
aImperial College, London
bPeter Medawar Building for Pathogen Research, Oxford University, Oxford
cMedical Research Council Clinical Trials Unit, London
dOxford NIHR Biomedical Research Centre, Oxford
eImperial College Healthcare NHS Trust, London
fKings College Hospital NHS Foundation Trust, London, UK.
Correspondence to Dr Elizabeth Hamlyn, Caldecot Centre, Kings College Hospital NHS Foundation Trust, London SE5 9RS, UK. Tel: +44 203 299 1119; fax: +44 203 299 3486; e-mail: firstname.lastname@example.org
Received 6 June, 2011
Revised 9 January, 2012
Accepted 27 January, 2012
This study was presented at the 18th Conference on Retroviruses and Opportunistic Infections, Boston, 2011.