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Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection

Hamlyn, Elizabetha,f; Hickling, Stephenb; Porter, Kholoudc; Frater, Johnb,d; Phillips, Rodneyb; Robinson, Marka; Mackie, Nicola E.e; Kaye, Stevea; McClure, Myraa; Fidler, Saraha; on behalf of the SPARTAC Investigators

doi: 10.1097/QAD.0b013e328351e721
Research Letters

CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus.

aImperial College, London

bPeter Medawar Building for Pathogen Research, Oxford University, Oxford

cMedical Research Council Clinical Trials Unit, London

dOxford NIHR Biomedical Research Centre, Oxford

eImperial College Healthcare NHS Trust, London

fKings College Hospital NHS Foundation Trust, London, UK.

Correspondence to Dr Elizabeth Hamlyn, Caldecot Centre, Kings College Hospital NHS Foundation Trust, London SE5 9RS, UK. Tel: +44 203 299 1119; fax: +44 203 299 3486; e-mail: e.hamlyn@nhs.net

Received 6 June, 2011

Revised 9 January, 2012

Accepted 27 January, 2012

This study was presented at the 18th Conference on Retroviruses and Opportunistic Infections, Boston, 2011.

© 2012 Lippincott Williams & Wilkins, Inc.