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AIDS:
doi: 10.1097/QAD.0b013e32835143e3
Research Letters

Regional differences in predictive accuracy of WHO immunologic failure criteria

Kiragga, Agnes N.a; Castelnuovo, Barbaraa; Kamya, Moses R.a,b; Moore, Richardc; Manabe, Yukari C.a,c

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Abstract

We compared the performance of the WHO immunologic criteria for treatment failure among Uganda and American patients. Antiretroviral treatment-naive patients with a CD4 T-cell count less than 200 cells/μl or AIDS at enrollment on a nonnucleoside reverse transcriptase inhibitors-based regimen for more than 1 year were selected. For all criteria, the positive predictive value was significantly higher in the American compared with the Ugandan patients. Population-specific guidelines should be developed using large African cohorts to identify more specific and sensitive criteria.

© 2012 Lippincott Williams & Wilkins, Inc.

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