We compared the performance of the WHO immunologic criteria for treatment failure among Uganda and American patients. Antiretroviral treatment-naive patients with a CD4 T-cell count less than 200 cells/μl or AIDS at enrollment on a nonnucleoside reverse transcriptase inhibitors-based regimen for more than 1 year were selected. For all criteria, the positive predictive value was significantly higher in the American compared with the Ugandan patients. Population-specific guidelines should be developed using large African cohorts to identify more specific and sensitive criteria.
aCollege of Health Sciences, Infectious Diseases Institute
bDepartment of Medicine, College of Health Sciences, Makerere University Kampala, Uganda
cJohns Hopkins Bloomberg School of Public Health, Divisions of Infectious Diseases and Clinical Pharmacology, Baltimore, MD, USA.
Correspondence to Agnes N. Kiragga, College of Health Sciences, Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda. Tel: +256 414307200; fax: +256 414307290; e-mail: firstname.lastname@example.org
Received 19 September, 2011
Revised 2 January, 2012
Accepted 10 January, 2012