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Prevalent tuberculosis and mortality among HAART initiators

Westreich, Daniela; Fox, Matthew P.b,c; Van Rie, Anneliesd; Maskew, Mhairic

doi: 10.1097/QAD.0b013e328351f6b8
Research Letters

The effect of tuberculosis on mortality in people initiating highly-active antiretroviral therapy (HAART) remains unclear; here, we strengthened a previous cohort analysis. Multivariate Cox proportional hazards models were used to assess the association of baseline tuberculosis and time to all-cause mortality among HAART initiators. In reanalysis, treatment for tuberculosis at time of HAART initiation remained unassociated with increased risks of all-cause mortality, with adjusted hazard ratios ranging from 1.00 to 1.09.

aDepartment of Obstetrics and Gynecology, Duke Global Health Institute, Duke University, Durham, North Carolina

bDepartment of Epidemiology, School of Public Health, Center for Global Health and Development, Boston University, Boston Massacusetts, USA

cHealth Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

dDepartment of Epidemiology, University of North Carolina, Chapel Hill, USA.

Correspondence to Daniel Westreich, PhD, Department of Obstetrics and Gynecology, Duke University Medical Center, Box 3084, Medical Center, Durham, NC 27710, USA. E-mail: daniel.westreich@duke.edu

Received 6 October, 2011

Revised 18 January, 2012

Accepted 30 January, 2012

© 2012 Lippincott Williams & Wilkins, Inc.